Advisor(s)
Abstract(s)
Squaraine dyes have recently attracted interest as potential second generation photosensitizers for photodynamic
therapy. Several cationic aminosquaraine dyes bearing benzoselenazole terminal nuclei were
synthezised and their cytotoxic activity was tested against four different human tumor cell lines – breast
(MCF-7), non-small cell lung (NCI-H460), cervical (HeLa) and hepatocellular (HepG2) carcinomas – and
against a non-tumor porcine liver primary cell line (PLP2), both in the absence of light and under
irradiation. All dyes, which displayed strong absorption within the phototherapeutic window, were found
to exhibit photodynamic activity and were shown to be, in most cases, more cytotoxic, both in the dark
and upon irradiation, than their benzothiazole analogues.
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Pedagogical Context
Citation
Magalhães, Álvaro F.; Graça, Vânia C.; Calhelha, Ricardo C.; Ferreira Machado, I. L.; Vieira Ferreira, L. F.; Ferreira, Isabel C.F.R.; Santos, Paulo F. (2019). Synthesis, photochemical and in vitro cytotoxic evaluation of benzoselenazole-based aminosquaraines. Photochemical and Photobiological Sciences. ISSN 1474-905X. 18, p. 336-342