Logo do repositório
 
Publicação

Synthesis, photochemical and in vitro cytotoxic evaluation of benzoselenazole-based aminosquaraines

2019Artigo científico Acesso aberto
Ver registo simples
dc.contributor.authorMagalhães, Álvaro F.
dc.contributor.authorGraça, Vânia C.
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorMachado, Isabel Ferreira
dc.contributor.authorFerreira, L.F. Vieira
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorSantos, Paulo F.
dc.date.accessioned2018-02-19T10:00:00Z
dc.date.accessioned2020-01-03T17:07:16Z
dc.date.available2018-01-19T10:00:00Z
dc.date.available2020-01-03T17:07:16Z
dc.date.issued2019
dc.description.abstractSquaraine dyes have recently attracted interest as potential second generation photosensitizers for photodynamic therapy. Several cationic aminosquaraine dyes bearing benzoselenazole terminal nuclei were synthezised and their cytotoxic activity was tested against four different human tumor cell lines – breast (MCF-7), non-small cell lung (NCI-H460), cervical (HeLa) and hepatocellular (HepG2) carcinomas – and against a non-tumor porcine liver primary cell line (PLP2), both in the absence of light and under irradiation. All dyes, which displayed strong absorption within the phototherapeutic window, were found to exhibit photodynamic activity and were shown to be, in most cases, more cytotoxic, both in the dark and upon irradiation, than their benzothiazole analogues.
dc.description.sponsorshipThe authors are grateful to the Foundation for Science and Technology (FCT, Portugal) and the FEDER for CIMO (UID/ AGR/00690/2013) and CQ-VR (UID/QUI/00616/2013) financial support.
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationMagalhães, Álvaro F.; Graça, Vânia C.; Calhelha, Ricardo C.; Ferreira Machado, I. L.; Vieira Ferreira, L. F.; Ferreira, Isabel C.F.R.; Santos, Paulo F. (2019). Synthesis, photochemical and in vitro cytotoxic evaluation of benzoselenazole-based aminosquaraines. Photochemical and Photobiological Sciences. ISSN 1474-905X. 18, p. 336-342en_EN
dc.identifier.doi10.1039/c8pp00201ken_EN
dc.identifier.issn1474-905X
dc.identifier.urihttp://hdl.handle.net/10198/20095
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.titleSynthesis, photochemical and in vitro cytotoxic evaluation of benzoselenazole-based aminosquarainesen_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FAGR%2F00690%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FQUI%2F00616%2F2013/PT
oaire.fundingStream5876
oaire.fundingStream5876
person.familyNameCalhelha
person.familyNameFerreira
person.givenNameRicardo C.
person.givenNameIsabel C.F.R.
person.identifier144781
person.identifier.ciencia-idF313-E3CE-554E
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridJ-2172-2014
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
relation.isAuthorOfPublication2d5d1a41-7561-4a01-871c-b4c97da35053
relation.isAuthorOfPublicationbd0d1537-2e03-41fb-b27a-140af9c35db8
relation.isAuthorOfPublication.latestForDiscoverybd0d1537-2e03-41fb-b27a-140af9c35db8
relation.isProjectOfPublicationcfb6e380-87c4-4772-8c2c-76799a53d6df
relation.isProjectOfPublicationf70c9068-bed3-4d95-b1be-9ce5d563cd22
relation.isProjectOfPublication.latestForDiscoverycfb6e380-87c4-4772-8c2c-76799a53d6df

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura indisponível
Nome:
164.pdf
Tamanho:
369.86 KB
Formato:
Adobe Portable Document Format
Ver/Abrir
Licença
A mostrar 1 - 1 de 1
Miniatura indisponível
Nome:
license.txt
Tamanho:
1.75 KB
Formato:
Plain Text
Descrição:
Ver/Abrir

Coleções

CIMO - Artigos em Revistas Indexados à WoS/Scopus