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Advisor(s)
Abstract(s)
Some mushrooms are a powerful source of bioactive compounds. lndeed, many pre-clinical
studies have been conducted in human tumour cell lines and in some cases a number of
compounds extracted from mushrooms have entered clinical trials [1]. Our previous results
showed that phenolic (methanolic and ethanolic) and polissacharidic extracts from Clitocybe
alexandri inhibited the growth of four human cell lines (lung, breast, colon and gastric cancer) [2].
The aim of the present work was to: i) further elucidate the mechanism of action of the ethanolic
extract that leads to the observed cell growth inhibition, by analysing the cell cycle profile of the
NCI-H460 cells treated with this extract and ii) identify and quantify the chemical compounds
present in the phenolic and polissacharidic extracts.
Description
Keywords
Citation
Vaz, Josiana A.; Almeida, Gabriela M.; Martins, Anabela; Vasconcelos, M. Helena; Ferreira, Isabel C.F.R. (2010). In vitro growth inhibitory activity of the Portuguese wild mushroom Clitocybe alexandri in human tumour cell lines. In 2º Encontro Nacional de Química Terapêutica. Porto