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In vitro growth inhibitory activity of the Portuguese wild mushroom Clitocybe alexandri in human tumour cell lines

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dc.contributor.authorVaz, Josiana A.
dc.contributor.authorAlmeida, Gabriela M.
dc.contributor.authorMartins, Anabela
dc.contributor.authorVasconcelos, M. Helena
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2011-02-14T09:45:50Z
dc.date.available2011-02-14T09:45:50Z
dc.date.issued2010
dc.description.abstractSome mushrooms are a powerful source of bioactive compounds. lndeed, many pre-clinical studies have been conducted in human tumour cell lines and in some cases a number of compounds extracted from mushrooms have entered clinical trials [1]. Our previous results showed that phenolic (methanolic and ethanolic) and polissacharidic extracts from Clitocybe alexandri inhibited the growth of four human cell lines (lung, breast, colon and gastric cancer) [2]. The aim of the present work was to: i) further elucidate the mechanism of action of the ethanolic extract that leads to the observed cell growth inhibition, by analysing the cell cycle profile of the NCI-H460 cells treated with this extract and ii) identify and quantify the chemical compounds present in the phenolic and polissacharidic extracts.
dc.identifier.citationVaz, Josiana A.; Almeida, Gabriela M.; Martins, Anabela; Vasconcelos, M. Helena; Ferreira, Isabel C.F.R. (2010). In vitro growth inhibitory activity of the Portuguese wild mushroom Clitocybe alexandri in human tumour cell lines. In 2º Encontro Nacional de Química Terapêutica. Portopor
dc.identifier.urihttp://hdl.handle.net/10198/3366
dc.language.isoengpor
dc.peerreviewedyespor
dc.relationPortuguese Wild Mushrooms: Chemical characterization and functional study of antiproliferative and proapoptotic properties in cancer cell lines
dc.relationPOTENCIAL NUTRACEUTICO DE COGUMELOS SILVESTRES DO NORDESTE DE PORTUGAL: ESTUDO DE PROPRIEDADES ANTIO-XIDANTES, ANTIPROLIFERATIVAS E INDUTORAS DA APOPTOSE
dc.titleIn vitro growth inhibitory activity of the Portuguese wild mushroom Clitocybe alexandri in human tumour cell linespor
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitlePortuguese Wild Mushrooms: Chemical characterization and functional study of antiproliferative and proapoptotic properties in cancer cell lines
oaire.awardTitlePOTENCIAL NUTRACEUTICO DE COGUMELOS SILVESTRES DO NORDESTE DE PORTUGAL: ESTUDO DE PROPRIEDADES ANTIO-XIDANTES, ANTIPROLIFERATIVAS E INDUTORAS DA APOPTOSE
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FAGR-ALI%2F110062%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F43653%2F2008/PT
oaire.citation.conferencePlacePortopor
oaire.citation.titleRevista Portuguesa de Farmácia, 2010, volume LII (nº4), 2º Encontro Nacional de Química Terapêuticapor
oaire.fundingStream5876-PPCDTI
person.familyNameVaz
person.familyNameMartins
person.familyNameFerreira
person.givenNameJosiana A.
person.givenNameAnabela
person.givenNameIsabel C.F.R.
person.identifier144781
person.identifier.ciencia-id171B-88BA-64F5
person.identifier.ciencia-id7B18-A810-6B93
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0002-6989-1169
person.identifier.orcid0000-0001-6218-4413
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridG-5488-2013
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id16305323200
person.identifier.scopus-author-id7203013518
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspor
rcaap.typeconferenceObjectpor
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