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Advisor(s)
Abstract(s)
Myrtus nivelli ileaves are widely used in the Algerian folk medicine, due toits healthpromoting
properties attributed to the phenolic composition. In this context, bioactivities of
the aqueous extract and its organic sub-fractions (ethyl acetate and butanol) were evaluated
with focus onantioxidant properties (free radicals’ scavenging activity, reducing power,
inhibition of β-carotene blanching andlipid peroxidation), anti-inflammatory potential.
(inhibition of NO production in lipopolysaccharide-stimulated RAW 264.7 macrophages),
cytotoxicity for human tumor cells and normal porcine liver primary cells, and antibacterial
activity against ten clinical isolates. The obtained results indicated high activities for all the
tested samples. The antioxidant activity was higher than that obtained for Trolox (positive
control), showing the ethylacetate fraction the highest activity as also the highest inhibition of
NO production (EC50= 104 ± 6 μg/mL) and cytotoxicity for all the tested tumor cell lines
(HeLa- 15.39±1 μg/mL, MCF-7- 16.12± 1μg/mL, NCI-H460-, HepG2-17.67±1 μg/mL and
49.01 ± 3 μg/mL). The butanol fraction and the crude aqueous extract presented the highest
antibacterial activity. Overall, this study highlights the potential of M. nivellii leaves in the
preparation of bioactive ingredients.
Description
Keywords
Myrtus nivellii Extract/fractions Antioxidant Anti-inflammatory Cytotoxicity Antibacterial