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Carbon-based magnetic nanocarrier for controlled drug release: a green synthesis approach
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Orientador(es)
Resumo(s)
In this study, hydrophilic magnetic nanoparticles were synthesized by green routes using
a methanolic extract of Rubus ulmifolius Schott flowers. The prepared magnetic nanoparticles were
coated with carbon-based shell for drug delivery application. The nanocomposites were further
chemically functionalized with nitric acid and, sequentially, with Pluronic® F68 (CMNPs-plur) to
enhance their colloidal stability. The resulting material was dispersed in phosphate buffer solution at
pH 7.4 to study the Doxorubicin loading. After shaking for 48 h, 99.13% of the drug was loaded by the
nanocomposites. Subsequently, the drug release was studied in different working phosphate buffer
solutions (i.e., PB pH 4.5, pH 6.0 and pH 7.4) to determine the efficiency of the synthesized material
for drug delivery as pH-dependent drug nanocarrier. The results have shown a drug release quantity
18% higher in mimicking tumor environment than in the physiological one. Therefore, this study
demonstrates the ability of CMNPs-plur to release a drug with pH dependence, which could be used
in the future for the treatment of cancer "in situ" by means of controlled drug release.
Descrição
Palavras-chave
Green routes Magnetic nanoparticles Drug delivery Cancer therapy Doxorubicin
Contexto Educativo
Citação
Oliveira, Jessica; Rodrigues, Raquel Oliveira; Barros, Lillian; Ferreira, Isabel C.F.R.; Marchesi, Luís; Koneracka, Martina; Jurikova, Alena; Zavisova, Vlasta; Gomes, Helder (2018). Carbon-based magnetic nanocarrier for controlled drug release: a green synthesis approach. C - Journal of Carbon Research. ISSN 2311-5629. 5:1, p. 1-16
Editora
MDPI