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Carbon-based magnetic nanocarrier for controlled drug release: a green synthesis approach

2018Journal article Open access
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dc.contributor.authorOliveira, Jéssica
dc.contributor.authorRodrigues, Raquel Oliveira
dc.contributor.authorBarros, Lillian
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorMarchesi, Luís
dc.contributor.authorKoneracka, Martina
dc.contributor.authorJurikova, Alena
dc.contributor.authorZavisova, Vlasta
dc.contributor.authorGomes, Helder
dc.contributor.authorOliveira, Jessíca
dc.date.accessioned2020-01-03T12:14:53Z
dc.date.available2020-01-03T12:14:53Z
dc.date.issued2018
dc.description.abstractIn this study, hydrophilic magnetic nanoparticles were synthesized by green routes using a methanolic extract of Rubus ulmifolius Schott flowers. The prepared magnetic nanoparticles were coated with carbon-based shell for drug delivery application. The nanocomposites were further chemically functionalized with nitric acid and, sequentially, with Pluronic® F68 (CMNPs-plur) to enhance their colloidal stability. The resulting material was dispersed in phosphate buffer solution at pH 7.4 to study the Doxorubicin loading. After shaking for 48 h, 99.13% of the drug was loaded by the nanocomposites. Subsequently, the drug release was studied in different working phosphate buffer solutions (i.e., PB pH 4.5, pH 6.0 and pH 7.4) to determine the efficiency of the synthesized material for drug delivery as pH-dependent drug nanocarrier. The results have shown a drug release quantity 18% higher in mimicking tumor environment than in the physiological one. Therefore, this study demonstrates the ability of CMNPs-plur to release a drug with pH dependence, which could be used in the future for the treatment of cancer "in situ" by means of controlled drug release.pt_PT
dc.description.sponsorshipThis research was funded by: Project POCI-01-0145-FEDER-006984 – Associate Laboratory LSRE-LCM funded by FEDER through COMPETE2020 - POCI – and by national funds through FCT (Fundação para a Ciência e a Tecnologia); RTChip4Theranostics, supported by Programa Operacional Regional do Norte—Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF) and by FCT. The authors are grateful to FCT, and FEDER under Programme PT2020 for financial support to CIMO (UID/AGR/00690/2013) and L. Barros contract. R.O.R. acknowledges the Ph.D. scholarship SFRH/BD/97658/2013 granted by FCT. This work was also supported by the Slovak Scientific Grant Agency projects VEGA 2/033/19.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationOliveira, Jessica; Rodrigues, Raquel Oliveira; Barros, Lillian; Ferreira, Isabel C.F.R.; Marchesi, Luís; Koneracka, Martina; Jurikova, Alena; Zavisova, Vlasta; Gomes, Helder (2018). Carbon-based magnetic nanocarrier for controlled drug release: a green synthesis approach. C - Journal of Carbon Research. ISSN 2311-5629. 5:1, p. 1-16pt_PT
dc.identifier.doi10.3390/c5010001pt_PT
dc.identifier.issn2311-5629
dc.identifier.urihttp://hdl.handle.net/10198/20006
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectGreen routespt_PT
dc.subjectMagnetic nanoparticlespt_PT
dc.subjectDrug deliverypt_PT
dc.subjectCancer therapypt_PT
dc.subjectDoxorubicinpt_PT
dc.titleCarbon-based magnetic nanocarrier for controlled drug release: a green synthesis approachpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FAGR%2F00690%2F2013/PT
oaire.citation.endPage16pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleC - Journal of Carbon Researchpt_PT
oaire.citation.volume5pt_PT
oaire.fundingStream5876
person.familyNameBarros
person.familyNameFerreira
person.familyNameGomes
person.familyNameOliveira
person.givenNameLillian
person.givenNameIsabel C.F.R.
person.givenNameHelder
person.givenNameJessíca
person.identifier469085
person.identifier144781
person.identifier.ciencia-id9616-35CB-D001
person.identifier.ciencia-id9418-CF95-9919
person.identifier.ciencia-id6218-1E19-13EE
person.identifier.ciencia-id4B1A-603E-572A
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0003-4910-4882
person.identifier.orcid0000-0001-6898-2408
person.identifier.orcid0000-0002-5367-9526
person.identifier.ridJ-3600-2013
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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