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Abstract(s)
In this work, a set of polyols was selected to be used as solvents for the extraction of phenolic
compounds from Juglans regia L. (walnut) leaves. Their biocompatibility and low toxicity makes them an
interesting option with potential industrial applications in the cosmetic, pharmaceutical or food areas. In
fact, some of them are already used as cosmetic ingredients and/or can be obtained from renewable raw
materials [1, 2].
Walnut leaves are an important source of bioactive molecules, such as phenolic compounds, suggesting
that their extracts (or pure components) could be used as natural antioxidants in different applications,
e.g. to replace synthetic antioxidants such as BHT (2,6-di-tert-butyl-4-methylphenol) or in dermatological
bases preventing oxidative damage [3,4].
Hence, the extraction performance of glycerol and a series of diols (1,2-etanodiol, 1,2-propanediol, 1,3-
propanediol, 1,3-butanediol, 1,2-pentanediol, 1,5-pentanediol, 1,2-hexanediol, 1,6-hexanediol) was
screened and the phenolic profile, characterized by HPLC-DAD. To evaluate the response, only the main
bioactive compounds present in the extract (acid 3-O-caffeyloquinic acid, quercetin 3-O-glucoside and
quercetin O-pentoside) were considered. In a second phase, for comparison purposes, the most
promising polyols were selected to prepare betaine based deep eutectic mixtures. After selecting the
best solvent, the remaining extraction conditions (time, temperature and water content) were further
optimized. These results provide relevant information for the design of an extraction process of phenolic
compounds from J. regia leaves using alternative solvents that could also play a role as a formulation
medium.
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Keywords
Citation
Vieira, Vanessa; Prieto, Miguel; Barros, Lillian; Coutinho, João A.P.; Ferreira, Isabel C.F.R.; Ferreira, Olga (2017). Polyols based solvents for the extraction of phenolic compounds from Juglans regia L. leaves. In 10º Encontro Nacional de Cromatografia. Bragança. ISBN 978-972-745-234-7
Publisher
Instituto Politécnico de Bragança