Advisor(s)
Abstract(s)
Galium aparine L. is a very disseminated plant in temperate zones, commonly known as clivers or bedstraw,
belonging to the Rubiaceae family and it is traditionally used for its medicinal applications. In this study, G.
aparine hydromethanolic extracts and infusions were prepared from air-dried and freeze-dried samples in order
to assess their phenolic profile, antioxidant, antimicrobial, and cytotoxic properties. All the studied extracts
revealed a similar phenolic profile, but the hydromethanolic extract obtained from the freeze-dried sample
presented the highest concentration of phenolic compounds, followed by the respective infusion and the airdried
sample hydromethanolic extract. The major compound detected in the extracts was 5-O-caffeoylquinic acid
(from 145 to 163 mg/g extract). Regarding the bioactivity, in general, the extracts presenting higher phenolic
concentrations also revealed enhanced bioactive properties. The EC50 values obtained in the antioxidant activity
assays ranged from 13.5 to 884 μg/mL, with the freeze-dried sample hydromethanolic extract presenting the
highest activity (13.5–555 μg/mL). Similar conclusions could be made in terms of antimicrobial properties, with
this extract showing the lowest MIC (1.85–15 mg/mL), MBC (3.75–7.5 mg/mL), and MFC (3.75–20 mg/mL)
values. None of the extracts revealed cytotoxicity. The results obtained in this study suggested that G. aparine
extracts can be a good source of phenolic compounds with antioxidant and antimicrobial properties.
Description
Keywords
Bioactive properties Dehydration process Galium aparine L. Phenolic compounds
Citation
Senio, Sylwia; Pereira, Carla; Vaz, Josiana; Sokovic, Marina; Barros, Lillian; Ferreira, Isabel C.F.R. (2018). Dehydration process influences the phenolic profile, antioxidant and antimicrobial properties of Galium aparine L. Industrial Crops and Products. ISSN 0926-6690. 120, p. 97-103