Orientador(es)
Resumo(s)
The present work aimed to characterize leaves, stems, and flowers of Carissa macrocarpa
(Eckl.) A.DC., by performing an analysis of the phenolic compounds by HPLC-DAD/ESI-MS,
correlating them with bioactive properties, such as antioxidant, anti-inflammatory, cytotoxic, and
antimicrobial activities. Thirty polyphenols were identified in the hydroethanolic extract, including
phenolic acids, flavan-3-ols, and flavonol glycosides derivatives (which presented the highest number
of identified compounds). However, flavan-3-ols showed the highest concentration in stems (mainly
owing to the presence of dimers, trimmers, and tetramers of type B (epi)catechin). Leaves were
distinguished by their high antioxidant and anti-inflammatory activities, as well as their bactericidal
e ect against E. coli, while stems presented a higher cytotoxic activity and bactericidal e ect against
Gram-positive bacteria. Moreover, a high correlation between the studied bioactivities and the
presence of phenolic compounds was also verified. The obtained results bring added value to the
studied plant species.
Descrição
Palavras-chave
Bioactivities Carissa macrocarpa Pearson's correlation Phenolic profile Plant aerial parts
Contexto Educativo
Citação
Souilem, Fedia; Dias, Maria Inês; Barros, Lillian; Calhelha, Ricardo C.; Alves, Maria José; Harzallah-Skhiri, Fethia; Ferreira, Isabel C.F.R. (2019). Phenolic profile and bioactive properties of carissa macrocarpa (Eckl.) A.DC.: An in vitro comparative study between leaves, stems, and flowers. Molecules. ISSN 1420-3049. 24, p. 1-12