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Phenolic profile and bioactive properties of carissa macrocarpa (Eckl.) A.DC.: An in vitro comparative study between leaves, stems, and flowers

2019Artigo científico Acesso aberto
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dc.contributor.authorSouilem, Fedia
dc.contributor.authorDias, Maria Inês
dc.contributor.authorBarros, Lillian
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorAlves, Maria José
dc.contributor.authorHarzallah-Skhiri, Fethia
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2018-02-19T10:00:00Z
dc.date.accessioned2020-01-03T17:07:02Z
dc.date.available2018-01-19T10:00:00Z
dc.date.available2020-01-03T17:07:02Z
dc.date.issued2019
dc.description.abstractThe present work aimed to characterize leaves, stems, and flowers of Carissa macrocarpa (Eckl.) A.DC., by performing an analysis of the phenolic compounds by HPLC-DAD/ESI-MS, correlating them with bioactive properties, such as antioxidant, anti-inflammatory, cytotoxic, and antimicrobial activities. Thirty polyphenols were identified in the hydroethanolic extract, including phenolic acids, flavan-3-ols, and flavonol glycosides derivatives (which presented the highest number of identified compounds). However, flavan-3-ols showed the highest concentration in stems (mainly owing to the presence of dimers, trimmers, and tetramers of type B (epi)catechin). Leaves were distinguished by their high antioxidant and anti-inflammatory activities, as well as their bactericidal e ect against E. coli, while stems presented a higher cytotoxic activity and bactericidal e ect against Gram-positive bacteria. Moreover, a high correlation between the studied bioactivities and the presence of phenolic compounds was also verified. The obtained results bring added value to the studied plant species.
dc.description.sponsorshipThe authors are grateful to the Foundation for Science and Technology (FCT, Portugal) and FEDER under Programmer PT2020 for financial support to CIMO (UID/AGR/00690/2019); L. Barros and M.I. Dias thank the national funding by FCT, P.I., through the institutional scientific employment program-contract for their contracts. The authors are also grateful to FEDER-Interreg España-Portugal programme for financial support through the project 0377_Iberphenol_6_E.
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationSouilem, Fedia; Dias, Maria Inês; Barros, Lillian; Calhelha, Ricardo C.; Alves, Maria José; Harzallah-Skhiri, Fethia; Ferreira, Isabel C.F.R. (2019). Phenolic profile and bioactive properties of carissa macrocarpa (Eckl.) A.DC.: An in vitro comparative study between leaves, stems, and flowers. Molecules. ISSN 1420-3049. 24, p. 1-12en_EN
dc.identifier.doi10.3390/molecules24091696en_EN
dc.identifier.urihttp://hdl.handle.net/10198/20086
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.subjectBioactivitiesen_EN
dc.subjectCarissa macrocarpaen_EN
dc.subjectPearson's correlationen_EN
dc.subjectPhenolic profileen_EN
dc.subjectPlant aerial partsen_EN
dc.titlePhenolic profile and bioactive properties of carissa macrocarpa (Eckl.) A.DC.: An in vitro comparative study between leaves, stems, and flowersen_EN
dc.typejournal article
dspace.entity.typePublication
person.familyNameDias
person.familyNameBarros
person.familyNameCalhelha
person.familyNameAlves
person.familyNameFerreira
person.givenNameMaria Inês
person.givenNameLillian
person.givenNameRicardo C.
person.givenNameMaria José
person.givenNameIsabel C.F.R.
person.identifier469085
person.identifier144781
person.identifier.ciencia-id2A13-4BE6-C7CF
person.identifier.ciencia-id9616-35CB-D001
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person.identifier.ciencia-idD618-B3A9-D312
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0001-8744-7814
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0001-8506-4393
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridM-8242-2013
person.identifier.ridJ-3600-2013
person.identifier.ridJ-2172-2014
person.identifier.ridM-6624-2016
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person.identifier.scopus-author-id54388787000
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person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id16400584800
person.identifier.scopus-author-id36868826600
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
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