Browsing by Author "Khan, Haroon"
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- Editorial: Herbal medical products and natural products targeting aging and age-related disorders-ethnopharmacological perspectivesPublication . Ullah, Hammad; Khan, Haroon; Prieto Lage, Miguel A.; Daglia, MariaThe population aged ≥60 years is growing worldwide. The World Health Organization (WHO) reported that the elderly population is expected to increase from 1 billion in 2020 to 1.4 billion in 2030 and 2.1 billion in 2050 (World Health Organization, 2022). This increase in life expectancy around the globe is accompanied with the enhancing frequency of agingassociated disorders, mainly due to the deterioration of metabolic, circulatory, and immune functioning. Inflammaging (chronic low-grade inflammation) is considered as one of the main drivers of the initiation and progression of diseases such as sarcopenia, osteoporosis, metabolic ailments, atherosclerosis, neurodegenerations, and carcinogenesis (Ullah et al., 2022). However, the actual etiology of these disorders is complicated due to the complex interaction of genes and environment, making their management more challenging in realworld circumstances. Currently, pharmacological interventions remained the mainstream option for the treatment of age-related diseases although drugs are associated with increased risk of the occurrence of adverse effects due to the increased susceptibility of adult population to drug effects, altered pharmacokinetic parameters, and use of polypharmacy, which may also increase the likelihood of drug interactions (Baldoni et al., 2010; Goldberg et al., 2022; Kwak et al., 2022).
- Kaempferol: a key emphasis to its anticancer potentialPublication . Imran, Muhammad; Salehi, Bahare; Sharifi-Rad, Javad; Gondal, Tanweer; Saeed, Farhan; Imran, Ali; Shahbaz, Muhammad; Fokou, Patrick; Khan, Haroon; Guerreiro, Susana G.; Martins, Natália; Estevinho, Leticia M.A marked decrease in human cancers, including breast cancer, bone cancer, and cervical cancer, has been linked to the consumption of vegetable and fruit, and the corresponding chemoprotective e ect has been associated with the presence of several active molecules, such as kaempferol. Kaempferol is a major flavonoid aglycone found in many natural products, such as beans, bee pollen, broccoli, cabbage, capers, cauliflower, chia seeds, chives, cumin, moringa leaves, endive, fennel, and garlic. Kaempferol displays several pharmacological properties, among them antimicrobial, anti-inflammatory, antioxidant, antitumor, cardioprotective, neuroprotective, and antidiabetic activities, and is being applied in cancer chemotherapy. Specifically, kaempferol-rich food has been linked to a decrease in the risk of developing some types of cancers, including skin, liver, and colon. The mechanisms of action include apoptosis, cell cycle arrest at the G2/M phase, downregulation of epithelial-mesenchymal transition (EMT)-related markers, and phosphoinositide 3-kinase/protein kinase B signaling pathways. In this sense, this article reviews data from experimental studies that investigated the links between kaempferol and kaempferol-rich food intake and cancer prevention. Even though growing evidence supports the use of kaempferol for cancer prevention, further preclinical and clinical investigations using kaempferol or kaempferol-rich foods are of pivotal importance before any public health recommendation or formulation using kaempferol.