Orientador(es)
Resumo(s)
Cytinus hypocistis whole plant and its three different parts (petals, stalks, and nectar) were chemically characterised
and their biological properties evaluated. A total of 17 phenolic compounds were identified, being
galloyl-bis-HHDP-glucose the most abundant. All the tested extracts showed high antioxidant capacity, with the
petals exhibiting the most promising results both in the OxHLIA (IC50 = 0.279 ng/mL) and TBARS
(IC50=0.342 ng/mL) assays. For the antidiabetic and anti-tyrosinase enzyme inhibitory assays, the stalk extract
presented the lowest IC50 values, 0.039 mg/mL and 0.09 mg/mL, respectively. Regarding antibacterial activity,
all tested extracts displayed broad-spectrum microbial inhibition against both Gram-positive and Gram-negative
bacteria. Similarly, all extracts displayed effective anti-proliferation activity against four tested tumour cell lines
(NCI–H460, HeLa, HepG2, and MCF-7), with no toxicity observed for a non-tumour cell line. Considering the
anti-inflammatory activity, the petals showed the highest nitric oxide inhibition (IC50 = 127 μg/mL). These
results point C. hypocistis as a promising source of health-promoting biomolecules.
Descrição
Palavras-chave
Bioactive properties Cellular/enzymatic assays Cytinus hypocistis (L.) L. Phytochemical profile Tannins
Contexto Educativo
Citação
Silva, Ana Rita; Pinela, José; Dias, Maria Inês; Calhelha, Ricardo C.; Alves, Maria José; Mocan, Andrei; García, Pablo A.; Barros, Lillian; Ferreira, Isabel C.F.R. (2020). Exploring the phytochemical profile of Cytinus hypocistis (L.) L. as a source of health-promoting biomolecules behind its in vitro bioactive and enzyme inhibitory properties. Food and Chemical Toxicology. ISSN 0278-6915. 136, p. 1-9