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Exploring the phytochemical profile of Cytinus hypocistis (L.) L. as a source of health-promoting biomolecules behind its in vitro bioactive and enzyme inhibitory properties

2020Journal article Open access
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dc.contributor.authorSilva, Ana Rita
dc.contributor.authorPinela, José
dc.contributor.authorDias, Maria Inês
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorAlves, Maria José
dc.contributor.authorMocan, Andrei
dc.contributor.authorGarcía, Pablo A.
dc.contributor.authorBarros, Lillian
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2018-02-19T10:00:00Z
dc.date.accessioned2020-06-22T10:18:43Z
dc.date.available2018-01-19T10:00:00Z
dc.date.available2020-06-22T10:18:43Z
dc.date.issued2020
dc.description.abstractCytinus hypocistis whole plant and its three different parts (petals, stalks, and nectar) were chemically characterised and their biological properties evaluated. A total of 17 phenolic compounds were identified, being galloyl-bis-HHDP-glucose the most abundant. All the tested extracts showed high antioxidant capacity, with the petals exhibiting the most promising results both in the OxHLIA (IC50 = 0.279 ng/mL) and TBARS (IC50=0.342 ng/mL) assays. For the antidiabetic and anti-tyrosinase enzyme inhibitory assays, the stalk extract presented the lowest IC50 values, 0.039 mg/mL and 0.09 mg/mL, respectively. Regarding antibacterial activity, all tested extracts displayed broad-spectrum microbial inhibition against both Gram-positive and Gram-negative bacteria. Similarly, all extracts displayed effective anti-proliferation activity against four tested tumour cell lines (NCI–H460, HeLa, HepG2, and MCF-7), with no toxicity observed for a non-tumour cell line. Considering the anti-inflammatory activity, the petals showed the highest nitric oxide inhibition (IC50 = 127 μg/mL). These results point C. hypocistis as a promising source of health-promoting biomolecules.
dc.description.sponsorshipThe authors are grateful to the Foundation for Science and Technology (FCT, Portugal) and European Regional Development Fund (FEDER) under Programme PT2020 for financial support to CIMO (UID/AGR/00690/2019). L. Barros, J. Pinela, M.I. Dias and R.C. Calhelha thank the national funding by FCT, P.I., through the institutional scientific employment program-contract for their contracts. The authors are also grateful to FEDER-Interreg España-Portugal programme for financial support through the project 0377_Iberphenol_6_E and TRANSCoLAB 0612_TRANS_CO_LAB_2_P.
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationSilva, Ana Rita; Pinela, José; Dias, Maria Inês; Calhelha, Ricardo C.; Alves, Maria José; Mocan, Andrei; García, Pablo A.; Barros, Lillian; Ferreira, Isabel C.F.R. (2020). Exploring the phytochemical profile of Cytinus hypocistis (L.) L. as a source of health-promoting biomolecules behind its in vitro bioactive and enzyme inhibitory properties. Food and Chemical Toxicology. ISSN 0278-6915. 136, p. 1-9en_EN
dc.identifier.doi10.1016/j.fct.2019.111071en_EN
dc.identifier.issn0278-6915
dc.identifier.urihttp://hdl.handle.net/10198/22329
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.relationTRANSCoLAB 0612_TRANS_CO_LAB_2_P
dc.subjectBioactive propertiesen_EN
dc.subjectCellular/enzymatic assaysen_EN
dc.subjectCytinus hypocistis (L.) L.en_EN
dc.subjectPhytochemical profileen_EN
dc.subjectTanninsen_EN
dc.titleExploring the phytochemical profile of Cytinus hypocistis (L.) L. as a source of health-promoting biomolecules behind its in vitro bioactive and enzyme inhibitory propertiesen_EN
dc.typejournal article
dspace.entity.typePublication
person.familyNameSilva
person.familyNamePinela
person.familyNameDias
person.familyNameCalhelha
person.familyNameAlves
person.familyNameBarros
person.familyNameFerreira
person.givenNameAna Rita
person.givenNameJosé
person.givenNameMaria Inês
person.givenNameRicardo C.
person.givenNameMaria José
person.givenNameLillian
person.givenNameIsabel C.F.R.
person.identifierABD-5857-2020
person.identifier469085
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person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0001-8506-4393
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridB-4466-2014
person.identifier.ridM-8242-2013
person.identifier.ridJ-2172-2014
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rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
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