Advisor(s)
Abstract(s)
The chemical composition of Gallesia integrifolia fruits essential oil was obtained by hydrodistillation using a modified Clevenger apparatus was investigated by gas chromatography coupled to mass spectrometry (GC/MS). In addition, the cytotoxicity activity against human tumor cell lines MCF-7 (breast adenocarcinoma), NCI-H460 (large cell lung carcinoma), HeLa (cervical carcinoma), and HepG2 (hepatocellular carcinoma), and non-tumor PLP2 (porcine liver primary cells) as well as the anti-inflammatory action was proposal. The compounds were predominantly organosulfates (2,8-dithianonane, dimethyl trisulfide, and lenthionine). Anti-inflammatory activity that provides 50% inhibition of nitric oxide production (55 µg/mL) of essential oil of the fruits. It also presents cytotoxic activity against MCF-7 (GI50 = 66 µg/mL), NCI-H-460 (GI50 = 147 µg/mL), HeLa (GI50 = 182 µg/mL) and HepG2 (GI50 = 240 µg/mL). The essential oil is more active in tumor cells than in non-tumor cells and the GI50 values for essential oil reported in our work support future studies.
Description
Keywords
Antitumoral Essential oil Inflammation Organosulfurates Pau d’alho
Pedagogical Context
Citation
Bortolucci, Wanessa de Campos; Raimundo, Keila Fernanda; Fernandez, Carla Maria Mariano; Calhelha, Ricardo C.; Ferreira, Isabel C.F.R.; Barros, Lillian; Gonçalves, José Eduardo; Linde, Giani Andrea; Colauto, Nelson Barros; Gazim, Zilda Cristiani (2021). Cytotoxicity and anti-inflammatory activities of Gallesia integrifolia (Phytolaccaceae) fruit essential oil. Natural Product Research. ISSN 1478-6419. , p. 1-7