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Cytotoxicity and anti-inflammatory activities of Gallesia integrifolia (Phytolaccaceae) fruit essential oil

2021Journal article Open access
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dc.contributor.authorBortolucci, Wanessa C.
dc.contributor.authorRaimundo, Keila Fernanda
dc.contributor.authorFernandez, Carla Maria Mariano
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorBarros, Lillian
dc.contributor.authorGonçalves, José Eduardo
dc.contributor.authorLinde, Giani Andrea
dc.contributor.authorColauto, Nelson Barros
dc.contributor.authorGazim, Zilda Cristiani
dc.date.accessioned2018-02-19T10:00:00Z
dc.date.accessioned2021-11-22T14:46:33Z
dc.date.available2018-01-19T10:00:00Z
dc.date.available2021-11-22T14:46:33Z
dc.date.issued2021
dc.description.abstractThe chemical composition of Gallesia integrifolia fruits essential oil was obtained by hydrodistillation using a modified Clevenger apparatus was investigated by gas chromatography coupled to mass spectrometry (GC/MS). In addition, the cytotoxicity activity against human tumor cell lines MCF-7 (breast adenocarcinoma), NCI-H460 (large cell lung carcinoma), HeLa (cervical carcinoma), and HepG2 (hepatocellular carcinoma), and non-tumor PLP2 (porcine liver primary cells) as well as the anti-inflammatory action was proposal. The compounds were predominantly organosulfates (2,8-dithianonane, dimethyl trisulfide, and lenthionine). Anti-inflammatory activity that provides 50% inhibition of nitric oxide production (55 µg/mL) of essential oil of the fruits. It also presents cytotoxic activity against MCF-7 (GI50 = 66 µg/mL), NCI-H-460 (GI50 = 147 µg/mL), HeLa (GI50 = 182 µg/mL) and HepG2 (GI50 = 240 µg/mL). The essential oil is more active in tumor cells than in non-tumor cells and the GI50 values for essential oil reported in our work support future studies.en_EN
dc.description.sponsorshipThe authors thank Universidade Paranaense, UniCesumar, Foundation for Science and Technology (FCT, Portugal) and FEDER under Programme PT2020 for financial support to CIMO (UID/AGR/00690/2019) and to national funding by FCT, P.I., through the institutional scientific employment program-contract for R.C. Calhelhas contract, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brazil (CAPES) -finance code 001-, Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), and Fundação Araucária for the financial support and the fellowship.
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationBortolucci, Wanessa de Campos; Raimundo, Keila Fernanda; Fernandez, Carla Maria Mariano; Calhelha, Ricardo C.; Ferreira, Isabel C.F.R.; Barros, Lillian; Gonçalves, José Eduardo; Linde, Giani Andrea; Colauto, Nelson Barros; Gazim, Zilda Cristiani (2021). Cytotoxicity and anti-inflammatory activities of Gallesia integrifolia (Phytolaccaceae) fruit essential oil. Natural Product Research. ISSN 1478-6419. , p. 1-7en_EN
dc.identifier.doi10.1080/14786419.2021.1925270en_EN
dc.identifier.issn1478-6419
dc.identifier.urihttp://hdl.handle.net/10198/24267
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.relationMountain Research Centre
dc.subjectAntitumoralen_EN
dc.subjectEssential oilen_EN
dc.subjectInflammationen_EN
dc.subjectOrganosulfuratesen_EN
dc.subjectPau d’alhoen_EN
dc.titleCytotoxicity and anti-inflammatory activities of Gallesia integrifolia (Phytolaccaceae) fruit essential oilen_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMountain Research Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FAGR%2F00690%2F2019/PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameCalhelha
person.familyNameFerreira
person.familyNameBarros
person.givenNameRicardo C.
person.givenNameIsabel C.F.R.
person.givenNameLillian
person.identifier144781
person.identifier469085
person.identifier.ciencia-idF313-E3CE-554E
person.identifier.ciencia-id9418-CF95-9919
person.identifier.ciencia-id9616-35CB-D001
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0003-4910-4882
person.identifier.orcid0000-0002-9050-5189
person.identifier.ridJ-2172-2014
person.identifier.ridE-8500-2013
person.identifier.ridJ-3600-2013
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id36868826600
person.identifier.scopus-author-id35236343600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
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