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Advisor(s)
Abstract(s)
Methicillin-resistant S. aureus (MRSA) are a threat to public health as they frequently reveal
a multidrug-resistant pattern. Researchers all over the world are on an urgent hunt for new treatments
to help fight infections before antibiotics become obsolete, and some natural alternatives, such as
polyphenols, have already exhibited therapeutic properties. Therefore, this study aimed to determine
the phenolic profile, antioxidant capacity, and antimicrobial activity against MRSA of the leaf, fruit,
and stem bark extracts of Platanus hybrida. The polyphenols were extracted with a water/ethanol
(20:80) mixture and the methodology included HPLC-DAD, DPPH, FRAP, and CuPRAC. To address
this issue from a One Health perspective, the Kirby–Bauer disc diffusion method was performed
against nine MRSA strains from three different sources (livestock, wild animals, and humans).
Fourteen phenolics were identified and the leaf extract showed the highest phenolic content, followed
by the fruit extract. The leaf extract also showed the highest antioxidant capacity while the fruit
extract had the lowest antioxidant capacity. Both leaf and fruit extracts inhibited the growth of strains
from all sources, while the stem bark extract did not inhibit the growth of human strains. This work
highlights the complex chemical composition and the antioxidative and antimicrobial potential of
extracts derived from P. hydrida.
Description
Keywords
Antimicrobial activity Antioxidant activity Drug-resistant bacteria MRSA One health Phenolic compounds
Citation
Ribeiro, Jessica; Silva, Vanessa; Aires, Alfredo; Carvalho, Rosa; Barros, Lillian; Gaivão, Isabel; Igrejas, Gilberto; Poeta, Patrícia (2022). Platanus hybrida’s phenolic profile, antioxidant power, and antibacterial activity against methicillin-resistant staphylococcus aureus (MRSA). Horticulturae. eISSN 2311-7524. 8:3, p. 1-14