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Platanus hybrida’s phenolic profile, antioxidant power, and antibacterial activity against methicillin-resistant staphylococcus aureus (MRSA)

2022Journal article Open access
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dc.contributor.authorRibeiro, Jessica
dc.contributor.authorSilva, Vanessa
dc.contributor.authorAires, Alfredo
dc.contributor.authorCarvalho, Rosa Paula
dc.contributor.authorBarros, Lillian
dc.contributor.authorGaivão, Isabel
dc.contributor.authorIgrejas, Gilberto
dc.contributor.authorPoeta, Patrícia
dc.date.accessioned2022-05-13T10:31:15Z
dc.date.available2022-05-13T10:31:15Z
dc.date.issued2022
dc.description.abstractMethicillin-resistant S. aureus (MRSA) are a threat to public health as they frequently reveal a multidrug-resistant pattern. Researchers all over the world are on an urgent hunt for new treatments to help fight infections before antibiotics become obsolete, and some natural alternatives, such as polyphenols, have already exhibited therapeutic properties. Therefore, this study aimed to determine the phenolic profile, antioxidant capacity, and antimicrobial activity against MRSA of the leaf, fruit, and stem bark extracts of Platanus hybrida. The polyphenols were extracted with a water/ethanol (20:80) mixture and the methodology included HPLC-DAD, DPPH, FRAP, and CuPRAC. To address this issue from a One Health perspective, the Kirby–Bauer disc diffusion method was performed against nine MRSA strains from three different sources (livestock, wild animals, and humans). Fourteen phenolics were identified and the leaf extract showed the highest phenolic content, followed by the fruit extract. The leaf extract also showed the highest antioxidant capacity while the fruit extract had the lowest antioxidant capacity. Both leaf and fruit extracts inhibited the growth of strains from all sources, while the stem bark extract did not inhibit the growth of human strains. This work highlights the complex chemical composition and the antioxidative and antimicrobial potential of extracts derived from P. hydrida.pt_PT
dc.description.sponsorshipThis work was supported by the projects UIDB/CVT/00772/2020 and LA/P/0059/2020 funded by the Portuguese Foundation for Science and Technology (FCT). This work was also supported by the Associate Laboratory for Green Chemistry-LAQV, which is financed by national funds from FCT/MCTES (UIDB/50006/2020 and UIDP/50006/2020) funded by FCT. The authors acknowledge the financial support of FCT by national funds under the project UIDB/04033/2020. Vanessa Silva is grateful to FCT for financial support through PhD grant SFRH/BD/137947/2018. To FCT, Portugal for financial support through national funds FCT/MCTES to CIMO (UIDB/00690/2020) and the contract of L. Barros through the institutional scientific employment program-contract. This work was supported.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRibeiro, Jessica; Silva, Vanessa; Aires, Alfredo; Carvalho, Rosa; Barros, Lillian; Gaivão, Isabel; Igrejas, Gilberto; Poeta, Patrícia (2022). Platanus hybrida’s phenolic profile, antioxidant power, and antibacterial activity against methicillin-resistant staphylococcus aureus (MRSA). Horticulturae. eISSN 2311-7524. 8:3, p. 1-14pt_PT
dc.identifier.doi10.3390/horticulturae8030243pt_PT
dc.identifier.eissn2311-7524
dc.identifier.urihttp://hdl.handle.net/10198/25445
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationUIDB/CVT/00772/2020pt_PT
dc.relationLA/P/0059/2020pt_PT
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationCentre for the Research and Technology of Agro-Environmental and Biological Sciences
dc.relationalterado para: Antimicrobial resistance, clonal diversity and biofilm formation of Staphylococcus aureus and other staphylococci: A One Health approach to a global threat Integrating multiple ‘omics’ analysis of methicillin-resistant Staphylococcus aureus MRSA biofilms: a One Health approach to a global threat
dc.relationMountain Research Center
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAntimicrobial activitypt_PT
dc.subjectAntioxidant activitypt_PT
dc.subjectDrug-resistant bacteriapt_PT
dc.subjectMRSApt_PT
dc.subjectOne healthpt_PT
dc.subjectPhenolic compoundspt_PT
dc.titlePlatanus hybrida’s phenolic profile, antioxidant power, and antibacterial activity against methicillin-resistant staphylococcus aureus (MRSA)pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleCentre for the Research and Technology of Agro-Environmental and Biological Sciences
oaire.awardTitlealterado para: Antimicrobial resistance, clonal diversity and biofilm formation of Staphylococcus aureus and other staphylococci: A One Health approach to a global threat Integrating multiple ‘omics’ analysis of methicillin-resistant Staphylococcus aureus MRSA biofilms: a One Health approach to a global threat
oaire.awardTitleMountain Research Center
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50006%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04033%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBD%2F137947%2F2018/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.citation.issue3pt_PT
oaire.citation.startPage243pt_PT
oaire.citation.titleHorticulturaept_PT
oaire.citation.volume8pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamPOR_NORTE
oaire.fundingStream6817 - DCRRNI ID
person.familyNameBarros
person.givenNameLillian
person.identifier469085
person.identifier.ciencia-id9616-35CB-D001
person.identifier.orcid0000-0002-9050-5189
person.identifier.ridJ-3600-2013
person.identifier.scopus-author-id35236343600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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