Blood flow of bubbles moving in microchannels with bifurcations

Bento, David; Lopes, Sara Helena Carvalho; Maia, Inês; Pereira, Ana I.; Fernandes, Carla S.; Miranda, João Mário; Lima, Rui A.

Publication

Blood flow of bubbles moving in microchannels with bifurcations

2019Book part

dc.contributor.author	Bento, David
dc.contributor.author	Lopes, Sara Helena Carvalho
dc.contributor.author	Maia, Inês
dc.contributor.author	Pereira, Ana I.
dc.contributor.author	Fernandes, Carla S.
dc.contributor.author	Miranda, João Mário
dc.contributor.author	Lima, Rui A.
dc.date.accessioned	2020-03-20T11:39:33Z
dc.date.available	2020-03-20T11:39:33Z
dc.date.issued	2019
dc.description.abstract	The gas embolism is a well-known phenomenon. Previous studies have been performed to understand the formation, the behavior and the influence of air bubbles in microcirculation. This study aims to investigate the flow of bubbles in a microchannel network with bifurcations. For that purpose, a microchannel network was fabricated by soft lithography. The working fluids used were composed by sheep red blood cells (RBCs) suspended in dextran 40 and two different hematocrits were studied, 5% and 10%. The in vitro blood flow was analyzed for a flow rate of lO ~-tllmin, by using an inverted microscope and a high-speed camera. It was possible to visualize the formation of the bubbles and their behavior along the network. The results show that the passage of air bubbles influences the cells local concentration, since a higher concentration of cells was seen upstream to the bubble and lower concentrations downstream to the bubble.	pt_PT
dc.description.sponsorship	This work was supported by Fundação para a Ciência e a Tecnologia (FCT), Portugal, under the strategic grants UID/EMS/04077/2019, UID/EEA/04436/2019 and UID/EMS/00532/2019. The authors are also grateful for the partial funding of FCT through the projects POCI-01-0145-FEDER-016861 (ref: PTDC/QEQ-FIT/4287/2014), NORTE-01-0145- FEDER-029394, NORTE-01-0145-FEDER-030171, funded by COMPETE2020, NOR1E2020, PORTUGAL2020, and FEDER. D. Bento acknowledges the PhD scholarship SFRH/BD/911921 2012 granted by FCT.	pt_PT
dc.description.version	info:eu-repo/semantics/publishedVersion	pt_PT
dc.identifier.citation	Bento, D.; Lopes, S.; Maia, I.; Pereira, Ana I.; Fernandes, Carla S.; Miranda, J.M.; Lima, R. (2019). Blood flow of bubbles moving in microchannels with bifurcations. In Lecture Notes in Computational Vision and Biomechanics. [S.l.]: Springer Nature. Vol 34, p. 571-577. ISBN 978-3-030-32039-3	pt_PT
dc.identifier.doi	10.1007/978-3-030-32040-9_57	pt_PT
dc.identifier.isbn	978-3-030-32039-3
dc.identifier.uri	http://hdl.handle.net/10198/21072
dc.language.iso	eng	pt_PT
dc.peerreviewed	yes	pt_PT
dc.rights.uri	http://creativecommons.org/licenses/by-nc/4.0/	pt_PT
dc.subject	Blood flow	pt_PT
dc.subject	Gas embolism	pt_PT
dc.subject	Microcirculation	pt_PT
dc.subject	Bifurcations networks	pt_PT
dc.title	Blood flow of bubbles moving in microchannels with bifurcations	pt_PT
dc.type	book part
dspace.entity.type	Publication
oaire.citation.endPage	577	pt_PT
oaire.citation.startPage	571	pt_PT
oaire.citation.title	Lecture Notes in Computational Vision and Biomechanics	pt_PT
oaire.citation.volume	34	pt_PT
person.familyName	Pereira
person.familyName	Fernandes
person.givenName	Ana I.
person.givenName	Carla S.
person.identifier.ciencia-id	0716-B7C2-93E4
person.identifier.ciencia-id	F319-3D67-9DB7
person.identifier.orcid	0000-0003-3803-2043
person.identifier.orcid	0000-0002-3138-7493
person.identifier.rid	F-3168-2010
person.identifier.rid	A-4269-2015
person.identifier.scopus-author-id	15071961600
person.identifier.scopus-author-id	8253740700
rcaap.rights	openAccess	pt_PT
rcaap.type	bookPart	pt_PT
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