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Advisor(s)
Abstract(s)
The gas embolism is a well-known phenomenon. Previous studies
have been performed to understand the formation, the behavior and the influence
of air bubbles in microcirculation. This study aims to investigate the flow of
bubbles in a microchannel network with bifurcations. For that purpose, a
microchannel network was fabricated by soft lithography. The working fluids
used were composed by sheep red blood cells (RBCs) suspended in dextran 40
and two different hematocrits were studied, 5% and 10%. The in vitro blood
flow was analyzed for a flow rate of lO ~-tllmin, by using an inverted microscope
and a high-speed camera. It was possible to visualize the formation of the
bubbles and their behavior along the network. The results show that the passage
of air bubbles influences the cells local concentration, since a higher concentration
of cells was seen upstream to the bubble and lower concentrations
downstream to the bubble.
Description
Keywords
Blood flow Gas embolism Microcirculation Bifurcations networks
Citation
Bento, D.; Lopes, S.; Maia, I.; Pereira, Ana I.; Fernandes, Carla S.; Miranda, J.M.; Lima, R. (2019). Blood flow of bubbles moving in microchannels with bifurcations. In Lecture Notes in Computational Vision and Biomechanics. [S.l.]: Springer Nature. Vol 34, p. 571-577. ISBN 978-3-030-32039-3