Orientador(es)
Resumo(s)
Hydroethanolic extracts of cardoon petioles collected at sixteen growth stages (P1–P16) were characterized in terms of their phenolic composition and bioactive potential (antioxidant, cytotoxic, anti-inflammatory, and antimicrobial activities). Fifteen phenolic compounds were tentatively identified (i.e., ten phenolic acids and five flavonoid glycosides); the main compounds were 5-O-caffeoylquinic and 1,5-di-O-caffeoylquinic acids. Samples collected at early maturity (P1–P4) presented a weak positive correlation between the higher content in polyphenols (P3: 101-mg/g extract) and better inhibition capacity against thiobarbituric acid reactive substance formation (TBARS; P3: IC50 = 5.0 µg/mL). Samples at intermediate maturation stages (P9) presented higher cytotoxic and anti-inflammatory potential. Moreover, immature petioles showed greater antihemolytic (OxHLIA; P4: IC50 = 65 and 180 µg/mL for Δt of 60 and 120 min, respectively) and antibacterial activity. The antifungal activity varied depending on the maturation stage and the fungi strain. In conclusion, the maturation stage may greatly affect the polyphenols composition and content and the bioactive potential of cardoon petioles.
Descrição
Palavras-chave
Anti-inflammatory activity Antimicrobial properties Antioxidant activity Cardoon Oxidative hemolysis Phenolic composition Seasonal changes
Contexto Educativo
Citação
Mandim, Filipa; Petropoulos, Spyridon A.; Dias, Maria Inês; Pinela, José; Kostić, Marina; Soković, Marina; Santos-Buelga, Celestino; Ferreira, Isabel C.F.R.; Barros, Lillian (2021). Phenolic composition and biological properties of cynara cardunculus l. Var. altilis petioles: Influence of the maturity stage. Antioxidants. ISSN 2076-3921. 10:12, p. 1-19