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Advisor(s)
Abstract(s)
The integrity of the genome is under constant threat from both endogenous and exogenous factors that
induce oxidative stress and accelerate ageing. The demand for natural and organic cosmetics is rising due
to the harmful effects of synthetic genotoxic agents on human health and the environment. Elderberry
(Sambucus nigra L.), a fruit rich in bioactive compounds such as polyphenols, has demonstrated significant
antioxidant properties. This study aimed to evaluate elderberry extract’s chemical characterization
and biological activities in peripheral blood mononuclear cells exposed to streptonigrin and H2O2, both
known for causing DNA damage. The antigenotoxic evaluation and antioxidant assays (ABTS and DPPH)
were conducted to assess its biological properties. Using the Comet assay enhanced with formamidopyrimidine-
DNA glycosylase (Fpg) to detect oxidized purines, we found that elderberry extract significantly
reduced DNA damage. These findings suggest that elderberry has potential as a natural alternative to synthetic
ingredients in cosmetics, offering protective benefits against DNA damage and contributing to antiageing
and skin health.
Description
Keywords
Elderberry Oxidative damage Bioactive compounds Polyphenols Antioxidant properties Cosmetics
Pedagogical Context
Citation
Gonçalves, Sara; Peixoto, Francisco; da Silveria, Tayse F. F.; Barros, Lillian; Gaivão, Isabel (2024). Antigenotoxic and cosmetic potential of elderberry (Sambucus nigra) extract: protection against oxidative DNA damage. Food & Function. ISSN 2042-6496. 15:21, p. 10795-10810
Publisher
Royal Society of Chemistry