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Antigenotoxic and cosmetic potential of elderberry (Sambucus nigra) extract: protection against oxidative DNA damage

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dc.contributor.authorGonçalves, Sara
dc.contributor.authorPeixoto, Francisco P.
dc.contributor.authorSilveira, Tayse F. F. da
dc.contributor.authorBarros, Lillian
dc.contributor.authorGaivão, Isabel
dc.date.accessioned2025-02-11T10:25:03Z
dc.date.available2025-02-11T10:25:03Z
dc.date.issued2024
dc.description.abstractThe integrity of the genome is under constant threat from both endogenous and exogenous factors that induce oxidative stress and accelerate ageing. The demand for natural and organic cosmetics is rising due to the harmful effects of synthetic genotoxic agents on human health and the environment. Elderberry (Sambucus nigra L.), a fruit rich in bioactive compounds such as polyphenols, has demonstrated significant antioxidant properties. This study aimed to evaluate elderberry extract’s chemical characterization and biological activities in peripheral blood mononuclear cells exposed to streptonigrin and H2O2, both known for causing DNA damage. The antigenotoxic evaluation and antioxidant assays (ABTS and DPPH) were conducted to assess its biological properties. Using the Comet assay enhanced with formamidopyrimidine-DNA glycosylase (Fpg) to detect oxidized purines, we found that elderberry extract significantly reduced DNA damage. These findings suggest that elderberry has potential as a natural alternative to synthetic ingredients in cosmetics, offering protective benefits against DNA damage and contributing to antiageing and skin health.pt_PT
dc.description.sponsorshipThis work was supported by the projects UIDB/00772/2020 (https://doi.org/10.54499/UIDB/00772/2020) funded by the Portuguese Foundation for Science and Technology (FCT). The authors thank Dinis Diogo for providing the ingredients used in this research. The authors would like to thank Tiago Ferreira for helping with the statistical analysis. The authors are also grateful to the Foundation for Science and Technology (FCT, Portugal) for support through national funds FCT/MCTES (PIDDAC) to CIMO: UIDB/00690/2020 (https://doi.org/10.54499/UIDB/00690/2020) and UIDP/00690/ 2020 (https://doi.org/10.54499/UIDP/00690/2020); and SusTEC (LA/P/0007/2020, https://doi.org/10.54499/LA/P/0007/2020). L. Barros thanks FCT through the institutional scientific employment program–contract for her contract.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGonçalves, Sara; Peixoto, Francisco; da Silveria, Tayse F. F.; Barros, Lillian; Gaivão, Isabel (2024). Antigenotoxic and cosmetic potential of elderberry (Sambucus nigra) extract: protection against oxidative DNA damage. Food & Function. ISSN 2042-6496. 15:21, p. 10795-10810pt_PT
dc.identifier.doi10.1039/D4FO03217Apt_PT
dc.identifier.eissn2042-650X
dc.identifier.issn2042-6496
dc.identifier.urihttp://hdl.handle.net/10198/31166
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherRoyal Society of Chemistrypt_PT
dc.relationVeterinary and Animal Science Research Centre
dc.relationMountain Research Center
dc.relationMountain Research Center
dc.relationAssociate Laboratory for Sustainability and Tecnology in Mountain Regions
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectElderberrypt_PT
dc.subjectOxidative damagept_PT
dc.subjectBioactive compoundspt_PT
dc.subjectPolyphenolspt_PT
dc.subjectAntioxidant propertiespt_PT
dc.subjectCosmeticspt_PT
dc.titleAntigenotoxic and cosmetic potential of elderberry (Sambucus nigra) extract: protection against oxidative DNA damagept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleVeterinary and Animal Science Research Centre
oaire.awardTitleMountain Research Center
oaire.awardTitleMountain Research Center
oaire.awardTitleAssociate Laboratory for Sustainability and Tecnology in Mountain Regions
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00772%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0007%2F2020/PT
oaire.citation.endPage10810pt_PT
oaire.citation.issue21pt_PT
oaire.citation.startPage10795pt_PT
oaire.citation.titleFood & Functionpt_PT
oaire.citation.volume15pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameSilveira
person.familyNameBarros
person.givenNameTayse F. F. da
person.givenNameLillian
person.identifier469085
person.identifier.ciencia-id541E-97D4-A3E5
person.identifier.ciencia-id9616-35CB-D001
person.identifier.orcid0000-0002-9050-5189
person.identifier.ridJ-3600-2013
person.identifier.scopus-author-id35236343600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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