Virtual screening of a library of natural compounds against COX-2 protein

Shiraishi, Carlos S.H.; Souza, Sérgio F.; Prieto Lage, Miguel A.; Barros, Lillian; Abreu, Rui M.V.

http://hdl.handle.net/10198/26339

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Authors

Shiraishi, Carlos S.H.

Souza, Sérgio F.

Prieto Lage, Miguel A.

Barros, Lillian

Abreu, Rui M.V.

Abstract(s)

The use of nonsteroidal anti-inflammatory drugs (NSAIDs) in treating inflammatory diseases has been widespread, especially in treating rheumatoid arthritis. NSAIDs act mainly by promoting the inhibition of cyclooxygenase enzymes (COX-1 and COX-2), inducing significant anti-inflammatory, analgesic, and antipyretic activity. However, recent data show that prolonged use of NSAIDs can lead to cardiovascular side effects. Thus, the present work aims to identify COX-2 inhibitors alternatives from natural sources, specifically mushrooms, as an alternative to conventional inhibitors.

Keywords

COX-2 protein Research Subject Categories::FORESTRY, AGRICULTURAL SCIENCES and LANDSCAPE PLANNING::Product science::Food science

URI

http://hdl.handle.net/10198/26339

Citation

Shiraishi, Yoshiki; Souza, Sérgio F.; Prieto Lage, Miguel A.; Barros, Lillian; Abreu, Rui M.V. (2022). Virtual screening of a library of natural compounds against COX-2 protein. In Biovia Conference 2022. Biovia