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Virtual screening of a library of natural compounds against COX-2 protein

2022Conference poster Open access
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dc.contributor.authorShiraishi, Carlos S.H.
dc.contributor.authorSouza, Sérgio F.
dc.contributor.authorPrieto Lage, Miguel A.
dc.contributor.authorBarros, Lillian
dc.contributor.authorAbreu, Rui M.V.
dc.date.accessioned2023-01-05T16:35:37Z
dc.date.available2023-01-05T16:35:37Z
dc.date.issued2022
dc.description.abstractThe use of nonsteroidal anti-inflammatory drugs (NSAIDs) in treating inflammatory diseases has been widespread, especially in treating rheumatoid arthritis. NSAIDs act mainly by promoting the inhibition of cyclooxygenase enzymes (COX-1 and COX-2), inducing significant anti-inflammatory, analgesic, and antipyretic activity. However, recent data show that prolonged use of NSAIDs can lead to cardiovascular side effects. Thus, the present work aims to identify COX-2 inhibitors alternatives from natural sources, specifically mushrooms, as an alternative to conventional inhibitors.pt_PT
dc.description.sponsorshipThe authors are grateful to the Foundation for Science and Technology (FCT, Portugal) for financial support through national funds FCT/MCTES to the CIMO (UIDB/00690/2020); to the European Regional Development Fund (ERDF) through the Competitiveness and Internationalization Operational Program for financial support to the project 100% Figo (POCI-01-0247-FEDER-064977). S. Heleno and M. Carocho thank FCT for their individual employment program–contract (CEECIND/ 00831/2018, CEECIND/03040/2017), and L.Barros also thanks to the national funding by FCT through the institutional scientificemployment program–contract for her contract. C. Shirashi thank the project 100% Figos.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationShiraishi, Yoshiki; Souza, Sérgio F.; Prieto Lage, Miguel A.; Barros, Lillian; Abreu, Rui M.V. (2022). Virtual screening of a library of natural compounds against COX-2 protein. In Biovia Conference 2022. Bioviapt_PT
dc.identifier.urihttp://hdl.handle.net/10198/26339
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationMountain Research Center
dc.relationNot Available
dc.relationNot Available
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCOX-2 proteinpt_PT
dc.subjectResearch Subject Categories::FORESTRY, AGRICULTURAL SCIENCES and LANDSCAPE PLANNING::Product science::Food sciencept_PT
dc.titleVirtual screening of a library of natural compounds against COX-2 proteinpt_PT
dc.typeconference poster
dspace.entity.typePublication
oaire.awardTitleMountain Research Center
oaire.awardTitleNot Available
oaire.awardTitleNot Available
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND 2018/CEECIND%2F00831%2F2018%2FCP1578%2FCT0001/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND 2017/CEECIND%2F03040%2F2017%2FCP1403%2FCT0001/PT
oaire.citation.conferencePlaceBioviapt_PT
oaire.citation.titleBiovia Conference 2022pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamCEEC IND 2018
oaire.fundingStreamCEEC IND 2017
person.familyNameShiraishi
person.familyNamePrieto Lage
person.familyNameBarros
person.familyNameAbreu
person.givenNameCarlos S.H.
person.givenNameMiguel A.
person.givenNameLillian
person.givenNameRui M.V.
person.identifier107688
person.identifier469085
person.identifier.ciencia-id6C11-86D5-73AE
person.identifier.ciencia-id221E-1E00-AB74
person.identifier.ciencia-id9616-35CB-D001
person.identifier.ciencia-id0F19-0DE2-12A2
person.identifier.orcid0000-0002-4174-8985
person.identifier.orcid0000-0002-3513-0054
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0002-7745-8015
person.identifier.ridG-4516-2011
person.identifier.ridJ-3600-2013
person.identifier.scopus-author-id35937495700
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id7003290613
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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