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Publication
Antioxidant activity and cytotoxic effects of polar extracts from saffron (Crocus sativus L.) flowers
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Advisor(s)
Abstract(s)
Saffron is cultivated exclusively to obtain the stigma of its flowers, which represents less than
10% of the flower weight. In fact, to achieve a single kg of dried stigma, more than 60 kg of
floral bio-residues are produced. These bio-residues were reported as having high bioactivity
and important contents in bioactive compounds. Before considering the use of these bioresidues
in different applications, it is important to assess its cytotoxicity. Herein, the
antioxidant activity and cytotoxicity of saffron flower polar extracts were evaluated. All
samples showed antioxidant activity, despite the higher effectiveness of the hydroalcoholic
extract. Up to the concentrations corresponding to the EC50 values obtained in the antioxidant
activity assays, none of the extracts showed high cytotoxicity against Caco-2 cell lines.
Accordingly, saffron flowers might be used in different applications such as the development
of food supplements or pharmaceutical related products.
Description
Keywords
Crocus sativus Antioxidant activity Citotoxicity
Citation
Barreira, João C.M.; Rebelo, José Miguel; Costa, Carla; Costa, Anabela S.G.; Ferreira, Isabel C.F.R.; Teixeira, João P.; Oliveira, M.B.P.P. (2014). Antioxidant activity and cytotoxic effects of polar extracts from saffron (Crocus sativus L) flowers. In 12º Encontro de Química dos Alimentos. Lisboa. p. 320-323