Advisor(s)
Abstract(s)
Hypericum is a genus of flowering plants and presents a nearly worldwide distribution. The relevance of its species is mainly based on the occurrence of specialised secondary metabolites exhibiting a wide range of pharmaceutical and cosmeceutical properties. The most well-reported species in the last decade is H. perforatum, together with its exceptional polycyclic polyprenylated acylphloroglucinols metabolites. Several inhibitory enzyme properties such as anti-tyrosinase, anti-hyaluronidase, anti-collagenase, and anti-elastase, along with the relevant cosmeceutical anti-inflammatory and antimicrobial activities, have been reported in numerous biological studies concerning this genus. From 2010 to date were published more than 3000 articles; therefore, an updated summary of Hypericum species and their related cosmeceutical bioactive compounds is necessary. This detailed analysis will be mainly focused on cosmeceutical-related bioactivity, phytochemical composition, and the products and processes that have been developed using the generated knowledge. Despite all the progress made in recent years, which contributed to a state-of-the-art improvement, only a few studies regarding the genus have been dedicated to investigating the mechanisms of action and the safety (toxicology) of its bioactive compounds using well-validated methodologies. A strategic partnership between RD and vital cosmeceutical enterprises could be the requisite to promote the development of a higher number of efficient and marketable Hypericum-derived cosmeceutical products.
Description
Keywords
Bioactive compounds Biological properties Cosmeceutical application Hypericum genus Hypericum perforatum
Pedagogical Context
Citation
Silva, Ana Rita; Taofiq, Oludemi; Ferreira, Isabel C.F.R.; Barros, Lillian (2021) - Hypericum genus cosmeceutical application - a decade comprehensive review on its multifunctional biological properties. Industrial Crops and Products. ISSN 0926-6690. 159, p. 1-