CIMO - Resumos Indexados à WoS/Scopus
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- Adherence to therapeutic in outpatients: literature reviewPublication . Ribeiro, Maria Isabel; Nascimento, Luís; Roque, Fátima; Herdeiro, M.T.F.Non-adherence to therapeutic is a widespread problem that contributes to the worsening of chronic diseases and to increase the expenditure on health care [1-3]. Objective: To present a review of the literature on the subject "Adherence to therapy" in outpatients. Methods: A search was carried out in the Medline database and the combinations of words Medication, Adherence and Outpatients were used for the period from 2010 to 2017. including only articles that adopted the Morisky Medication Adherence Scale (MMAS) to measure adherence to medication and studies developed in hospital context. In addition, articles with non-conventional therapies were excluded, namely those that resorted to the use of medicinal plants. Information was collected on the place of the study, period, type of study, sample, pathology, adherence to therapy in terms of rate or score (mean) and factors identified as being associated with non-adherence to therapy. Results: The search retrieved 461 publications and 44 were included in the analysis. The included studies are from Europe, Asia, Africa and America. Most of the studies were observational (84.1%). The remaining studies were interventional studies (15.9%). There were, also, 4 multicenter studies. In most studies, the Morisky scale was used with 8 item and only 31.8% used the shorter scale with 4 items. The sample sizes ranged from 34 to 2595 chronic patients and were mostly non-probabilistic (convenience) (75%). The most common pathologies were: diabetes, hypertension, diabetic retinopathy and hypercholesterolemia (34.1%); psychiatric diseases (25%), cardiovascular diseases (18.2%), among others. Taking into account the variable "adherence to therapeutic", 84.5% of the studies used a dichotomous variable. The others determined the score (mean with associated standard deviation). In general, therapeutic adherence was low. Considering the adherence rates, the lowest were recorded in the treatment of hypercholesterolemia (7.4%) and the highest was recorded in the treatment of hypertension in patients with apnea (83%). It should be noted that the cut-off point did not remain the same in all studies. The factors most commonly referred to as being associated with non-adherence were age, forgetfulness, lack of social support, the complexity of intake and stopping medication when the patient feels better. Conclusion: Interventional studies show significant improvements in adherence, comparing the situation before and after the intervention. Therefore, it is a priority to implement measures that improve adherence to therapy. References 1. Conn VS, Ruppar TM, Chan KC, Dunbar-Jacob J, Pepper GA, Geest SD. Packaging interventions to increase medication adherence: systematic review and meta-analysis. Current Medical Research And Opinion 2015, 31(1):145-60. 2. Ababneh MA, Al-Azzam SI, Alzoubi KH, Rababa'h AM. Adherence in outpatients taking warfarin and its effect on anticoagulation control in Jordan. Int J Clin Pharm. 2016, 38(4):816-21. 3. Napolitano F, Napolitano P, Angelillo IF. Collaborative Working Group. Medication adherence among patients with chronic conditions in Italy. Eur J Public Health 2016 26(1):48-52.
- Biological activity of 6,7-dehydroroyleanone derivatives from Plectranthus aliciaePublication . Filipe, Márcia Santos; Dominguez, Eva; Isca, Vera; Pereira, Raquel; Mandim, Filipa; Calhelha, Ricardo C.; Diaz-Lanza, Ana María; Barros, Lillian; Rijo, PatríciaPlectranthus genus (Lamiaceae) is known to be rich in bioactive abietane royleanone-type diterpenes, such as 6,7-dehydroxyroyleanone (1, Fig. 1), which have been previously found in P. madagascariensis (var. aliciae Codd). This abietane royleanone presents moderate to significant to cytoxic activity against several cancer cell lines. Moreover, 1 has one hydroxyl group suitable for deri- vatization that can be explored to enhance the cytotoxic activity of lead com- pound 1. Based on this, the aim of the present work is to explore the obtention of 1, from P. aliciae aliciae (Codd) van Jaarsv. & T.J.Edwards., a subspecies of P. madagascariensis to be further used in the preparation of new derivatives with enhanced biological activities.
- Body composition and body image perception in portuguese and spanish college students: comparative study between overweight /obese and normal weight womenPublication . Pereira, Elza; Lacerda, Fernanda; Valador, Natacha; Ferro-Lebres, Vera; Arroyo-Izaga, MartaObjective: To evaluate body image perception and compare with real measures of body composition between overweight/obese and normal weight women college students. Subjects: The reported sample included 600 students from Portugal and Spain. Material and Methods: The anthropometry variables: weight, height, skinfolds, circumferences and body mass index, waist-hip ratio, percentage of body fat and fat-free mass- FFM were compared with reference values. The body image perception and satisfaction were estimated using Somatomorphic Matrix and Body Shape Questionnaire (BSQ34). With the difference between actual and ideal measures was obtained the dissatisfaction through body image. For data analysis was used t-test and Pearson correlation. Results:10,7% of the Spanish sample was overweight/obese. Statistical significance was found between real and ideal FFM (P<0,01), showing a medium body dissatisfaction. Fat mass was well estimated. The Portuguese measures are elapsing now. The results will be finished before the congress date. Conclusions: These results constitute a first approach of body image perception and satisfaction, in Portuguese and Spanish students. Recent studies consider the cultural thinness preoccupation, the weight prejudice and disturbances in body image, mainly a discrepancy between perceived and ideal body image, extending beyond the health risks associated with obesity, and have become a serious problem. And the effect of body size and composition feedback is more pronounced in overweighted. Our study shows the importance of public health actions in the education of body image perception and satisfaction in Portugal and Spain, as a measure preventing eating disorders and other mental disturbances, especially between overweight/obese women.
- Cistus ladanifer as a source of phenolic compounds with antifungal activityPublication . Barros, Lillian; Dueñas, Montserrat; Alves, Carlos Tiago; Silva, Sónia; Henriques, Mariana; Santos-Buelga, Celestino; Ferreira, Isabel C.F.R.A screening of the antifungal potential of phenolic extract of Cistus ladanifer from Northeast Portugal, against Candida species was performed. The extract was characterized by HPLC-DAD-ESI/MS. Phenolic acids and derivatives, ellagic acid derivatives and flavonoids, such as catechins, flavonols and flavones, were found in the sample. The most abundant group was ellagic acid derivatives in which punicalagin gallate, a derivative of punicalagin attached to gallic acid, was found in highest amount. These compounds could be related to the strong inhibition of C. albicans, C. glabrata and C. parapsilosis growth. Moreover, the best antifungal activity was against C. glabrata, where the studied extract was able to cause at least 3 Log of reduction at concentrations below 50 µg/mL and a total growth inhibition at concentrations above 625 µg/mL.
- Depressive symptoms and alcohol use among adolescentsPublication . Pinto, Isabel C.; Fraga, Sílvia; Ramos, ElisabeteAlcohol is the most consumed substance by young people, sometimes it’s associated with depressive symptoms. Objective: Assess the factors associated with alcohol use among 13-year-old teenagers, like depressive symptoms. Methods: Data of a population-based cohort of urban teenagers included cross-sectional information of 919 boys and 1016 girls collected by self-reported questionnaire. Depressive symptoms were evaluated using Beck Depressive Inventory II (BDI). The Mann-Whitney test was used to compare medians. Odds ratio (OR) and multiple linear regression (β) were performed to estimate the magnitude of associations with 95% confidence intervals (95%CI). The final model was adjusted for parents’ education, sports, smoking, have friends who drink and parents’ history of depression. Results: Overall 515(50.0%) girls and 425(44.9%) boys have experimented alcoholic beverages and, 48(4.7%) girls and 62(6.6%) boys have drunk(one drink at least once time per month) at 13-year-old. For both genders, after adjustment, being experimenter was significantly associated with parents’ education, tobacco use and friends who drink. In girls, characteristics that was significantly associated to be drinker were tobacco use OR=6.9(3.1-15.2) and friends who drink OR=6.4(2.7-15.2). In boys, to be drinker was associated with tobacco use OR=5.9(2.7-13.0), friends who drink OR=7.3(3.5-15.4) and cohabiting with people who drink OR=5.1(1.4-17.6). Adolescents who have drunk presented a high score in BDI [median(25p-75p)] in girls[6.01(2.00-10.00)vs.6.38(3.00-11.99),p=0.002)] and in boys[3.00(1.01-6.01)vs.3.99(1.01-6.99),p=0.039]. After adjustment, the association was not significant in girls(β=0.583,95%CI[-0.483;1.648]) in boys(β=0.623,95%CI[-0.170;1.417]). Conclusions: Among 13-year-old adolescents parents’ education, smoking and friends who drink were associated with drinking behaviour. After adjustment, depressive symptoms did not show a significant association with alcohol use.
- Free radical scavenging activity of different almond (Prunus dulcis) varietiesPublication . Barreira, João C.M.; Ferreira, Isabel C.F.R.; Oliveira, Beatriz; Pereira, J.A.Reactive oxygen species are known to be implicated in many cell disorders and in the development of many diseases including cardiovascular diseases atherosclerosis, cataracts, chronic inflammation or neurodegenerative diseases such as Alzheimer’s or Parkinson 's disease. Thus, synthetic antioxidants are widely used in the food industry, bur, because of their toxic and carcinogenic effects, their use is being restricted.
- From Apple Waste to Antimicrobial Solutions: A Review of Phenolics from PGI ‘Maçã de Alcobaça’ and Related CultivarsPublication . Ribeiro, Jessica; Silva, Vanessa; Dapkevicius, Maria de Lurdes N. E.; Igrejas, Gilberto; Barros, Lillian; Heleno, Sandrina A.; Reis, Filipa S.; Poeta, PatríciaApple by-products represent a valuable source of phenolic compounds with significant antimicrobial potential, aligning with sustainable strategies for waste valorisation within the circular bioeconomy. This review focuses on the phenolic profile and antimicrobial relevance of ‘Maçã de Alcobaça,’ a Protected Geographical Indication (PGI) apple variety from Portugal. The main phenolics identified include phloridzin, phloretin, chlorogenic acid, quercetin glycosides, catechin, epicatechin, and procyanidins, which exhibit broad-spectrum antibacterial activity, particularly against Gram-positive pathogens such as Staphylococcus aureus. Their structure-activity relationships and mechanisms of action, namely membrane disruption, enzyme inhibition, oxidative stress induction, and quorum sensing interference, are discussed. Different extraction methods and solvents influence phenolic yield and bioactivity, with ethyl acetate and hydromethanolic extracts generally showing stronger effects. Studies reveal the potential of phenolics to interact synergistically with antibiotics and the promising applications in food preservation, medical formulations, and antimicrobial packaging. Overall, apple-derived phenolics, particularly those derived from industrial by-products, have significant potential as natural antimicrobial agents. Further exploration of these phenolics in the context of One Health and antimicrobial resistance mitigation is recommended.
- Grape Winemaking By-Products: Current Valorization Strategies and Their Value as Source of Tannins with Applications in Food and FeedPublication . Echave, Javier; González Pereira, Antía; Jorge, Ana O. S.; Barciela, Paula; Nogueira-Marques, Rafael; Yuksek, Ezgi N.; Oliveira, María B. P. P.; Barros, Lillian; Prieto, Miguel A.Grape (Vitis vinifera L.) is one of the most extensively cultivated crops in temperate climates, with its primary fate being wine production, which is paired with a great generation of grape pomace (GP). GP contains a plethora of antioxidant phenolic compounds, being well-known for its high content of various tannins, liable for the astringency of this fruit. Winemaking produces a great mass of by-products that are rich in tannins. Grape seed (GSd) and pulp waste, as well as leaves and stems (GSt), are rich in condensed tannins (CTs), while its skin (GSk) contains more flavonols and phenolic acids. CTs are polymers of flavan-3-ols, and their antioxidant and anti-inflammatory properties are well-accounted for, being the subject of extensive research for various applications. CTs from the diverse fractions of grapefruit and grapevine share similar structures given their composition but diverge in their degree of polymerization, which can modulate their chemical interactions and may be present at around 30 to 80 mg/g, depending on the grape fraction. Thus, this prominent agroindustrial by-product, which is usually managed as raw animal feed or further fermented for liquor production, can be valorized as a source of tannins with high added value. The present review addresses current knowledge on tannin diversity in grapefruit and grapevine by-products, assessing the differences in composition, quantity, and degree of polymerization. Current knowledge of their reported bioactivities will be discussed, linking them to their current and potential applications in food and feed.
- Influence of socio-demographic issues in body mass index (bmi) of drug addicts in methadone maintenance treatmentPublication . Ferro-Lebres, Vera; Costa, Ana Filipa; Alves, Daniela; Custódio, Daniela; Natário, Liliana; Andrade, FernandoThe purpose of this study was to investigate the infl uence of social factors on the nutritional status of drug addicts. 60 drug addicts in methadone maintenance treatment of Integrated Response Center (CRI)of Bragança were evaluated. Nutritional assessment was performed by measuring the weight and height and then calculated the body mass index. The socio-demographic data were collected through a questionnaire constructed for this purpose. PASW 19.0 for Windows. The average body mass index (BMI) was 22.46 ± 3.36 kg/m2 and based on this parameter 13.3% were underweight, 65% normal weight, 20.0% overweight and 1.7% obesity grade I. BMI was signifi cantly higher in addicts who live with a spouse in relation to other housing contexts (p< 0.005). In terms of marital status, unmarried addicts had a significantly lower BMI compared to other situations. Individuals have an average of 4.10 ± 4.47 years of treatment and 78.3% performed less than 3 meals/day. The socio-demographic conditions must be taken into consideration in the process of intervention with this population. More studies must be performed in other to clarify other food behaviour variables in drug users populations.
- Maternal overweight and obesity versus breastfeeding successPublication . Lucas, Cláudia; Teixeira, Diana; Silvestre, Vera; Almeida-de-Souza, Juliana; Ferreira, Eva PintoMaternal Obesily has been associated with a poor lactation in animal models but these results are inconclusive on investigations ma de with Human. Because the prevalence of overweight and obesity is increasing dramatically among women in reproductive age mainly, in Portugal investigations lhat relate to the maternal obesity breastfeeding are necessary, which is the main purpose of this study warning of the importance of a pregnancy planned and this point to the importance of controlling weight.