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- Clinical case report: severe neonatal jaundice due to abo incompatibilityPublication . Pimentel, Maria Helena; Antão, CelesteA clinical situation in which foetal red blood cells carrying different surface antigens pass through the placenta into the maternal circulation. Following the initial exposure, the maternal immune system produces IgM-type antibodies. A second exposure triggers the rapid and massive production of IgG antibodies, which cross the placenta and bind to the foetus's red blood cells. Since the introduction of Rh immunoglobulin (RhIG) in 1968, the incidence has decreased significantly (Harmening, 2012). This disease can cause foetal anaemia, erythropoiesis with hepatosplenomegaly, increased bilirubin due to the destruction of red blood cells. In some cases, this can be fatal.