CIMO - Resumos Indexados à WoS/Scopus
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- Biological activity of 6,7-dehydroroyleanone derivatives from Plectranthus aliciaePublication . Filipe, Márcia Santos; Dominguez, Eva; Isca, Vera; Pereira, Raquel; Mandim, Filipa; Calhelha, Ricardo C.; Diaz-Lanza, Ana María; Barros, Lillian; Rijo, PatríciaPlectranthus genus (Lamiaceae) is known to be rich in bioactive abietane royleanone-type diterpenes, such as 6,7-dehydroxyroyleanone (1, Fig. 1), which have been previously found in P. madagascariensis (var. aliciae Codd). This abietane royleanone presents moderate to significant to cytoxic activity against several cancer cell lines. Moreover, 1 has one hydroxyl group suitable for deri- vatization that can be explored to enhance the cytotoxic activity of lead com- pound 1. Based on this, the aim of the present work is to explore the obtention of 1, from P. aliciae aliciae (Codd) van Jaarsv. & T.J.Edwards., a subspecies of P. madagascariensis to be further used in the preparation of new derivatives with enhanced biological activities.
- Cistus ladanifer as a source of phenolic compounds with antifungal activityPublication . Barros, Lillian; Dueñas, Montserrat; Alves, Carlos Tiago; Silva, Sónia; Henriques, Mariana; Santos-Buelga, Celestino; Ferreira, Isabel C.F.R.A screening of the antifungal potential of phenolic extract of Cistus ladanifer from Northeast Portugal, against Candida species was performed. The extract was characterized by HPLC-DAD-ESI/MS. Phenolic acids and derivatives, ellagic acid derivatives and flavonoids, such as catechins, flavonols and flavones, were found in the sample. The most abundant group was ellagic acid derivatives in which punicalagin gallate, a derivative of punicalagin attached to gallic acid, was found in highest amount. These compounds could be related to the strong inhibition of C. albicans, C. glabrata and C. parapsilosis growth. Moreover, the best antifungal activity was against C. glabrata, where the studied extract was able to cause at least 3 Log of reduction at concentrations below 50 µg/mL and a total growth inhibition at concentrations above 625 µg/mL.
- From Apple Waste to Antimicrobial Solutions: A Review of Phenolics from PGI ‘Maçã de Alcobaça’ and Related CultivarsPublication . Ribeiro, Jessica; Silva, Vanessa; Dapkevicius, Maria de Lurdes N. E.; Igrejas, Gilberto; Barros, Lillian; Heleno, Sandrina A.; Reis, Filipa S.; Poeta, PatríciaApple by-products represent a valuable source of phenolic compounds with significant antimicrobial potential, aligning with sustainable strategies for waste valorisation within the circular bioeconomy. This review focuses on the phenolic profile and antimicrobial relevance of ‘Maçã de Alcobaça,’ a Protected Geographical Indication (PGI) apple variety from Portugal. The main phenolics identified include phloridzin, phloretin, chlorogenic acid, quercetin glycosides, catechin, epicatechin, and procyanidins, which exhibit broad-spectrum antibacterial activity, particularly against Gram-positive pathogens such as Staphylococcus aureus. Their structure-activity relationships and mechanisms of action, namely membrane disruption, enzyme inhibition, oxidative stress induction, and quorum sensing interference, are discussed. Different extraction methods and solvents influence phenolic yield and bioactivity, with ethyl acetate and hydromethanolic extracts generally showing stronger effects. Studies reveal the potential of phenolics to interact synergistically with antibiotics and the promising applications in food preservation, medical formulations, and antimicrobial packaging. Overall, apple-derived phenolics, particularly those derived from industrial by-products, have significant potential as natural antimicrobial agents. Further exploration of these phenolics in the context of One Health and antimicrobial resistance mitigation is recommended.
- Grape Winemaking By-Products: Current Valorization Strategies and Their Value as Source of Tannins with Applications in Food and FeedPublication . Echave, Javier; González Pereira, Antía; Jorge, Ana O. S.; Barciela, Paula; Nogueira-Marques, Rafael; Yuksek, Ezgi N.; Oliveira, María B. P. P.; Barros, Lillian; Prieto, Miguel A.Grape (Vitis vinifera L.) is one of the most extensively cultivated crops in temperate climates, with its primary fate being wine production, which is paired with a great generation of grape pomace (GP). GP contains a plethora of antioxidant phenolic compounds, being well-known for its high content of various tannins, liable for the astringency of this fruit. Winemaking produces a great mass of by-products that are rich in tannins. Grape seed (GSd) and pulp waste, as well as leaves and stems (GSt), are rich in condensed tannins (CTs), while its skin (GSk) contains more flavonols and phenolic acids. CTs are polymers of flavan-3-ols, and their antioxidant and anti-inflammatory properties are well-accounted for, being the subject of extensive research for various applications. CTs from the diverse fractions of grapefruit and grapevine share similar structures given their composition but diverge in their degree of polymerization, which can modulate their chemical interactions and may be present at around 30 to 80 mg/g, depending on the grape fraction. Thus, this prominent agroindustrial by-product, which is usually managed as raw animal feed or further fermented for liquor production, can be valorized as a source of tannins with high added value. The present review addresses current knowledge on tannin diversity in grapefruit and grapevine by-products, assessing the differences in composition, quantity, and degree of polymerization. Current knowledge of their reported bioactivities will be discussed, linking them to their current and potential applications in food and feed.