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|Title:||Synthesis of aminodiarylamines in the thieno[3,2-b]pyridine series and effects on tumor cell growth inhibition, cell cycle and apoptosis|
|Authors:||Calhelha, Ricardo C.|
Ferreira, Isabel C.F.R.
Abreu, Rui M.V.
Vale-Silva, Luís A.
Lima, Raquel T.
Alvelos, M. Inês
Vasconcelos, M. Helena
Queiroz, Maria João R.P.
|Publisher:||Sociedade Portuguesa de Ciências Farmacêuticas|
|Citation:||Calhelha, Ricardo C.; Ferreira, Isabel C.F.R.; Abreu, Rui M.V.; Vale-Silva, Luís A.; Pinto, Eugénia; Lima, Raquel T.; Alvelos, M. Inês; Vasconcelos, M. Helena; Queiroz, Maria-João R.P. (2011) - Synthesis of aminodiarylamines in the thieno[3,2-b]pyridine series and effects on tumor cell growth inhibition, cell cycle and apoptosis. In III Congress of the Portuguese Society of Pharmaceutical Sciences and IX Spanish-Portuguese conference on controlled drug delivery. Porto|
|Abstract:||Several series of compounds that include the thienopyridine scaffold have been reported as inhibitors of known cancer therapeutic targets or as inhibitors of cell proliferation in tumor cell lines [1,2]. Our research group has already synthesized several thieno[3,2-b]pyridine derivatives by Pd-catalyzed C-C (Suzuki and Sonogashira) and C-N (Buchwald-Hartwig) couplings and some of them have presented tumor cell growth inhibitory activity in cell lines [3- 5].|
|Appears in Collections:||BB - Resumos em Proceedings Não Indexados ao ISI/Scopus|
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