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Title: Determination of the cell-free layer in circular PDMS microchannels
Authors: Cerdeira, T.
Lima, R.
Oliveira, M.
Monteiro, Fernando C.
Ishikawa, Takuji
Imai, Yohsuke
Yamaguchi, Takami
Keywords: Cell-free layer
Issue Date: 2010
Publisher: Taylor and Francis
Citation: Cerdeira, T.; Lima, R.; Oliveira, M.; Monteiro, Fernando C.; Ishikawa, T.; Imai, Y.; Yamaguchi, T. (2010) - Determination of the cell-free layer in circular PDMS microchannels. In COMPUTATIONAL VISION AND MEDICAL IMAGING PROCESSING VIP Image. Porto. ISBN 978-0-415-57041-1.
Abstract: In microcirculation the cell-free layer is believed to reduce the friction between red blood cells (RBCs) and endothelial cells and consequently reduce blood flow resistance. However, the complex formation of the cell-free layer has not yet been convincingly described mainly due to multi-physical and hemorheological factors that affect this phenomenon. In this experimental work, we study the effect of hematocrit (Hct) on the thickness of the cell-free layer in straight circular polydimethylsiloxane (PDMS) microchannels. The channels studied are 73 ± 2 mm in diameter, flexible and circular to mimic blood vessels. The images are captured using confocal microscopy and are post-processed using Image J and MATLAB. The formation of a cell-free layer is clearly visible in the images captured and by using a combination of image analysis techniques we are able to detect an increase in the cell-free layer thickness as Hct decreases.
Peer review: yes
ISBN: 978-0-415-57041-1
Appears in Collections:DTM - Artigos em Proceedings Não Indexados ao ISI/Scopus

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