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Title: Synthesis and antioxidant activity of new methoxylated di(hetero)arylamines derivatives of thieno[3,2-b]pyridines,
Author: Queiroz, Maria João R.P.
Calhelha, Ricardo C.
Abreu, Rui M.V.
Ferreira, Isabel C.F.R.
Issue Date: 2008
Citation: Queiroz, Maria-João R.P.; Calhelha, Ricardo C.; Abreu, Rui M.V.; Ferreira, Isabel C.F.R. (2008) - Synthesis and antioxidant activity of new methoxylated di(hetero)arylamines derivatives of thieno[3,2-b]pyridines. In International Conference in Medicinal Chemistry: Interfacing Chemical Biology, Natural Products and Drug Discovery. Angers
Abstract: Due to their isosterism with pyrrolopyridines or quinolines, thieno[3,2-b]pyridines have attracted much attention because of their potential biological activity [1]. We have prepared the 6-bromothieno[3,2-b]pyridine 1, following a known method used by us for benzo[b]thiophene compounds [2], as component for palladium-catalyzed Buchwald-Hartwig coupling with methoxylated ani lines. The corresponding di(hetero)arylamines 2a-2d were obtained in good yields and were fully characterized (Scheme 1).
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