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A convenient high performance computing (HPC) methodology for virtual screening using Autodock 4
Publication . Abreu, Rui M.V.; Froufe, Hugo J.C.; Ferreira, Isabel C.F.R.; Queiroz, Maria João R.P.
Synthesis and antioxidant activity of new methoxylated di(hetero)arylamines derivatives of thieno[3,2-b]pyridines,
Publication . Queiroz, Maria João R.P.; Calhelha, Ricardo C.; Abreu, Rui M.V.; Ferreira, Isabel C.F.R.
Due to their isosterism with pyrrolopyridines or quinolines, thieno[3,2-b]pyridines have attracted much
attention because of their potential biological activity [1].
We have prepared the 6-bromothieno[3,2-b]pyridine 1, following a known method used by us for
benzo[b]thiophene compounds [2], as component for palladium-catalyzed Buchwald-Hartwig coupling with methoxylated ani lines. The corresponding di(hetero)arylamines 2a-2d were obtained in good yields and were fully characterized (Scheme 1).
Electrochemical evaluation of the redox-properties of diarylamines in the 2,3-dimethylbenzo[b]thiophene series
Publication . Falcão, Soraia; Abreu, Rui M.V.; Ferreira, Isabel C.F.R.; Vilas-Boas, Miguel; Queiroz, Maria João R.P.
QSAR studies on di(hetero)arylamines derivatives of benzo[b]thiophenes as free radical scavengers
Publication . Abreu, Rui M.V.; Ferreira, Isabel C.F.R.; Queiroz, Maria João R.P.
Synthetic antioxidants are widely used in food industry y, but because of
toxic and carcinogenic effects revealed by some compounds such as
BHA and BHT, their use is being restricted. The pursuit for novel
compounds with antioxidant properties gained higher significance,
since these compounds may contribute for the prevention of diseases in
which free radicals are implicated.
Lipid peroxidation inhibition, free radical scavenging activity and electrochemical behaviour of a dihydroxylated di(hetero)arylamine
Publication . Ferreira, Isabel C.F.R.; Barros, Lillian; Falcão, Soraia; Vilas-Boas, Miguel; Queiroz, Maria João R.P.
The skin provides the first line of defense against oxidative damage
induced by environmental factors, having an elaborated antioxidant
system designed to deal with free radicals and oxidative stress. However,
under severe stress conditions this biological response is not sufficient,
leading to oxidative damage and, in consequence, to skin disorders,
immunosuppresion, premature skin aging and ultimately cancer.
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Fundação para a Ciência e a Tecnologia
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POCI
Número da atribuição
POCI/QUI/59407/2004