Utilize este identificador para referenciar este registo: http://hdl.handle.net/10198/10308
Título: Cell-free layer (CFL) measurements in complex geometries: contractions and bifurcations
Autor: Novais, Susana
Pinho, Diana
Bento, David
Pinto, Elmano
Yaginuma, Tomoko
Fernandes, Carla S.
Garcia, Valdemar
Pereira, Ana I.
Lima, José
Mujika, Maite
Oliveira, Mónica S. N.
Dias, Ricardo P.
Arana, Sergio
Lima, R.
Palavras-chave: Cell-free layer
Bifurcation
Confluence
Microchannel
Data: 2014
Editora: Springer
Citação: Novais, Susana; Pinho, Diana; Bento, David; Pinto, Elmano; Yaginuma, Tomoko; Fernandes, Carla S.; Garcia, Valdemar; Pereira, Ana I.; Lima, José; Mujika, Maite Oliveira, Mónica S. N.; Dias, Ricardo P.; Arana, Sergio; Lima, R. (2014) - Cell-free layer (CFL) measurements in complex geometries: contractions and bifurcations. In Lima, Rui [et al.](eds.) Visualization and Simulation of Complex Flows in Biomedical Engineering. Lecture Notes in Computational Vision and Biomechanics. Springer. 12, p.119-132. ISBN 978-94-007-7768-2
Resumo: In this chapter we discuss the cell-free layer (CFL) developed adjacent to the wall of microgeometries containing complex features representative of the microcirculation, such as contractions, expansions, bifurcations and confluences. The microchannels with the different geometries were made of polydimethylsiloxane (PDMS) and we use optical techniques to evaluate the cell-free layer for red blood cells (RBC) suspensions with different hematocrit (Hct). The images are captured using a high-speed video microscopy system and the thickness of the cell free layer was measured using both manual and automatic image analysis techniques. The results show that in in vitro microcirculation, the hematocrit and the geometrical configuration have a major impact on the CFL thickness. In particular, the thickness of the cell-free layer increases as the fluid flows through a contraction-expansion sequence and that this increase is enhanced for lower hematocrit. In contrast, the flow rates tested in this studies did not show a clear influence on the CFL thickness.
Peer review: yes
URI: http://hdl.handle.net/10198/10308
ISBN: 978-94-007-7768-2
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