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Cell-free layer (CFL) measurements in complex geometries: contractions and bifurcations

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dc.contributor.authorNovais, Susana
dc.contributor.authorPinho, Diana
dc.contributor.authorBento, David
dc.contributor.authorPinto, Elmano
dc.contributor.authorYaginuma, Tomoko
dc.contributor.authorFernandes, Carla S.
dc.contributor.authorGarcia, Valdemar
dc.contributor.authorPereira, Ana I.
dc.contributor.authorLima, José
dc.contributor.authorMujika, Maite
dc.contributor.authorOliveira, Mónica S.N.
dc.contributor.authorDias, Ricardo P.
dc.contributor.authorArana, Sergio
dc.contributor.authorLima, Rui A.
dc.date.accessioned2014-09-04T13:53:18Z
dc.date.available2014-09-04T13:53:18Z
dc.date.issued2014
dc.description.abstractIn this chapter we discuss the cell-free layer (CFL) developed adjacent to the wall of microgeometries containing complex features representative of the microcirculation, such as contractions, expansions, bifurcations and confluences. The microchannels with the different geometries were made of polydimethylsiloxane (PDMS) and we use optical techniques to evaluate the cell-free layer for red blood cells (RBC) suspensions with different hematocrit (Hct). The images are captured using a high-speed video microscopy system and the thickness of the cell free layer was measured using both manual and automatic image analysis techniques. The results show that in in vitro microcirculation, the hematocrit and the geometrical configuration have a major impact on the CFL thickness. In particular, the thickness of the cell-free layer increases as the fluid flows through a contraction-expansion sequence and that this increase is enhanced for lower hematocrit. In contrast, the flow rates tested in this studies did not show a clear influence on the CFL thickness.por
dc.description.sponsorshipThe authors acknowlcdge the financiaI suppart provided by: PTDC/SAUBEB/l08728/2008, PTDC/SAU-BEB/l05650/2008, PTDC/EME-MFEI099109/2008 and PTDC/SAU-ENB/116929/2010 from FCT (Science and Technnlogy Foundation), COMPETE, QREN and European Union (FEDER). The authors are graterul to Mônica Oliveira for many valuable camments on this study.
dc.identifier.citationNovais, Susana; Pinho, Diana; Bento, David; Pinto, Elmano; Yaginuma, Tomoko; Fernandes, Carla S.; Garcia, Valdemar; Pereira, Ana I.; Lima, José; Mujika, Maite Oliveira, Mónica S. N.; Dias, Ricardo P.; Arana, Sergio; Lima, R. (2014). Cell-free layer (CFL) measurements in complex geometries: contractions and bifurcations. In Lima, Rui [et al.](eds.) Visualization and Simulation of Complex Flows in Biomedical Engineering. Lecture Notes in Computational Vision and Biomechanics. Springer. 12, p.119-132. ISBN 978-94-007-7768-2por
dc.identifier.isbn978-94-007-7768-2
dc.identifier.urihttp://hdl.handle.net/10198/10308
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherSpringerpor
dc.relationHemo-Networks - Experimental and computational investigations of the factors influencing blood flow in microvascular networks.
dc.relationANEURYSM - Hemodynamic Study in Cerebral Aneurysms
dc.relationBIOMIMETIC - A biomimetic microdevice for the diagnosis of erythrocytes diseases based on their deformability
dc.subjectCell-free layerpor
dc.subjectBifurcationpor
dc.subjectConfluencepor
dc.subjectMicrochannelpor
dc.titleCell-free layer (CFL) measurements in complex geometries: contractions and bifurcationspor
dc.typebook part
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oaire.awardTitleHemo-Networks - Experimental and computational investigations of the factors influencing blood flow in microvascular networks.
oaire.awardTitleANEURYSM - Hemodynamic Study in Cerebral Aneurysms
oaire.awardTitleBIOMIMETIC - A biomimetic microdevice for the diagnosis of erythrocytes diseases based on their deformability
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FSAU-BEB%2F108728%2F2008/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FEME-MFE%2F099109%2F2008/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FSAU-ENB%2F116929%2F2010/PT
oaire.citation.endPage132por
oaire.citation.startPage119por
oaire.citation.titleVisualization and Simulation of Complex Flows in Biomedical Engineeringpor
oaire.citation.volumeLecture Notes in Computational Vision and Biomechanics,12por
oaire.fundingStream5876-PPCDTI
oaire.fundingStream5876-PPCDTI
oaire.fundingStream5876-PPCDTI
person.familyNamePinho
person.familyNameFernandes
person.familyNameGarcia
person.familyNamePereira
person.familyNameLima
person.familyNameDias
person.familyNameLima
person.givenNameDiana
person.givenNameCarla S.
person.givenNameValdemar
person.givenNameAna I.
person.givenNameJosé
person.givenNameRicardo P.
person.givenNameRui A.
person.identifierR-000-8GD
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person.identifier.orcid0000-0002-3941-2438
person.identifier.orcid0000-0003-3803-2043
person.identifier.orcid0000-0001-7902-1207
person.identifier.orcid0000-0003-1503-998X
person.identifier.orcid0000-0003-3428-637X
person.identifier.ridA-4269-2015
person.identifier.ridF-3168-2010
person.identifier.ridL-3370-2014
person.identifier.ridH-5157-2016
person.identifier.scopus-author-id8253740700
person.identifier.scopus-author-id15071961600
person.identifier.scopus-author-id55851941311
person.identifier.scopus-author-id7102885151
person.identifier.scopus-author-id18437397800
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspor
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