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Advisor(s)
Abstract(s)
O arsenal de antibióticos existentes está desatualizado. É imperioso encontrar novas
formulações, melhorar as existentes e analisar padrões de resultados laboratoriais.
Os aminoglicosídeos, de ação bactericida, são usados em infeções por
Enterobactereaceaes. A utilização da Gentamicina, de origem natural, e da Amicacina,
de origem semissintética, é limitada pelo efeito ototóxico e nefrotóxico.
As Enterobactereaceaes são um problema grave: trata-se de uma família numerosa, que
partilha plasmídeos, com capacidade de biofilme, existentes no bioma e oportunistas em
colonização.
Pretendeu-se analisar a atividade da Amicacina e da Gentamicina em
Enterobactereaceaes de processos infeciosos de utentes da ULSNE, assim como verificar
se há variação em situações recorrentes de infeção e em situações de multirresistência.
O presente estudo tem cariz retrospetivo, correlacional, assenta numa base de dados
fornecida pela Glintt®.
, com os resultados de identificação de Enterobactereaceaes e TSA
para Gentamicina e Amicacina dos resultados dos utentes. Como marcador de
multirresistência foram usados os Carbapenem.
Os dados são relativos a 10 242 processos de infeção de 7 395 pacientes com mais de 18
anos, com análises feitas no SPC-ULSNE, no período compreendido entre 2010 e 2022.
Foi estudada a origem dos isolados, as características da população, a distribuição
geográfica, a prevalência bacteriana e a atividade dos antibióticos.
Observou-se uma prevalência de infeções por E. coli (64,3 %), maioritariamente de
infeções urinárias, sensíveis tanto à Amicacina (95.09%) como à Gentamicina (92.5%),
e comportamento semelhante em Carbapenem (99,35%) como marcadores de resistência.
Observaram-se resistências a Gentamicina pelos géneros Providencia (81,10%),
Klebsiella (28,40%), menos surpreendentes Proteus (19,30%) e Morganella (16,30%).
Conclui-se que estes são antibióticos com ação positiva sobre as Enterobactereaceaes.
No entanto, alguns géneros começam a demonstrar resistência à Gentamicina.
The existing arsenal of antibiotics is outdated. It is imperative to find new formulations, improve existing ones and analyze patterns of laboratory results. Aminoglycosides, with bactericidal action, are used in infections caused by Enterobacteriaceae. The use of gentamicin, of natural origin, and amikacin, of semi- synthetic origin, is limited by their ototoxic and nephrotoxic effects. Enterobactereaceae are a serious problem: they are a large family, which shares plasmids, with biofilm capacity, existing in the biome, and opportunistic in colonization. The aim was to analyze the activity of amikacin and gentamicin on Enterobacteriaceae from infectious processes in ULSNE users, as well as verifying whether there is variation in recurrent infection situations and multidrug resistance situations. The present study is retrospective, correlational in nature, based on a database provided by Glintt®, with the identification results of Enterobactereaceae and TSA for Gentamicin and Amikacin from user results. Carbapenem was used as a multidrug resistance marker. The data relates to 10,242 infection processes from 7,395 patients over 18 years of age, with analyzes carried out at SPC-ULSNE, in the period between 2010 and 2022. The origin of the isolates, the characteristics of the population, the distribution geographical location, bacterial prevalence and antibiotic activity. There was a prevalence of E.coli infections (64.3%), mostly urinary infections, sensitive to both Amikacin (95.09%) and Gentamicin (92.5%), and similar behavior with carbapenem (99.35%) as resistance markers. Resistance to gentamicin was observed in the genera Providencia (81.10%), Klebsiella (28.40%), and less surprisingly Proteus (19.30%) and Morganella (16.30%). It is concluded that these are antibiotics with positive action on Enterobactereaceae. However, some genera are beginning to demonstrate resistance to Gentamicin.
The existing arsenal of antibiotics is outdated. It is imperative to find new formulations, improve existing ones and analyze patterns of laboratory results. Aminoglycosides, with bactericidal action, are used in infections caused by Enterobacteriaceae. The use of gentamicin, of natural origin, and amikacin, of semi- synthetic origin, is limited by their ototoxic and nephrotoxic effects. Enterobactereaceae are a serious problem: they are a large family, which shares plasmids, with biofilm capacity, existing in the biome, and opportunistic in colonization. The aim was to analyze the activity of amikacin and gentamicin on Enterobacteriaceae from infectious processes in ULSNE users, as well as verifying whether there is variation in recurrent infection situations and multidrug resistance situations. The present study is retrospective, correlational in nature, based on a database provided by Glintt®, with the identification results of Enterobactereaceae and TSA for Gentamicin and Amikacin from user results. Carbapenem was used as a multidrug resistance marker. The data relates to 10,242 infection processes from 7,395 patients over 18 years of age, with analyzes carried out at SPC-ULSNE, in the period between 2010 and 2022. The origin of the isolates, the characteristics of the population, the distribution geographical location, bacterial prevalence and antibiotic activity. There was a prevalence of E.coli infections (64.3%), mostly urinary infections, sensitive to both Amikacin (95.09%) and Gentamicin (92.5%), and similar behavior with carbapenem (99.35%) as resistance markers. Resistance to gentamicin was observed in the genera Providencia (81.10%), Klebsiella (28.40%), and less surprisingly Proteus (19.30%) and Morganella (16.30%). It is concluded that these are antibiotics with positive action on Enterobactereaceae. However, some genera are beginning to demonstrate resistance to Gentamicin.
Description
Keywords
Amicacina Gentamicina Enterobactereaceaes Sensibilidade Resistência Infeção