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Blood flow behavior in microchannels: past, current and future trends

dc.contributor.authorLima, Rui A.
dc.contributor.authorIshikawa, Takuji
dc.contributor.authorImai, Yohsuke
dc.contributor.authorYamaguchi, Takami
dc.date.accessioned2012-08-29T11:04:55Z
dc.date.available2012-08-29T11:04:55Z
dc.date.issued2012
dc.description.abstractOver the years, various experimental methods have been applied in an effort to understand the blood flow behavior in microcirculation. Most of our current knowledge in microcirculation is based on macroscopic flow phenomena such as Fahraeus effect and Fahraeus-Linqvist effect. The development of optical experimental techniques has contributed to obtain possible explanations on the way the blood flows through microvessels. Although the past results have been encouraging, detailed studies on blood flow behavior at a microscopic level have been limited by several factors such as poor spatial resolution, difficulty to obtain accurate measurements at such small scales, optical errors arisen from walls of the microvessels, high concentration of blood cells, and difficulty in visualization of results due to insufficient computing power and absence of reliable image analysis techniques. However, in recent years, due to advances in computers, optics, and digital image processing techniques, it has become possible to combine a conventional particle image velocimetry (PIV) system with an inverted microscope and consequently improve both spatial and temporal resolution. The present review outlines the most relevant studies on the flow properties of blood at a microscale level by using past video-based methods and current micro-PIV and confocal micro-PIV techniques. Additionally the most recent computational fluid dynamics studies on microscale hemodynamics are also reviewed.por
dc.identifier.citationLima, R.; Ishikawa, T.; Imai, Y.; Yamaguchi, T. (2012). Blood flow behavior in microchannels: past, current and future trends . In Single and two-Phase Flows on Chemical and Biomedical Engineering. p. 513-547. ISBN 978-1-60805-295-0.por
dc.identifier.isbn978-1-60805-295-0
dc.identifier.urihttp://hdl.handle.net/10198/7409
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherBentham Sciencepor
dc.relationANEURYSM - Hemodynamic Study in Cerebral Aneurysms
dc.relationHemo-Networks - Experimental and computational investigations of the factors influencing blood flow in microvascular networks.
dc.subjectIn vitro bloodpor
dc.subjectMicrocirculationpor
dc.subjectConfocal micro-PIV/PTVpor
dc.subjectBlood rheologypor
dc.titleBlood flow behavior in microchannels: past, current and future trendspor
dc.typebook part
dspace.entity.typePublication
oaire.awardTitleANEURYSM - Hemodynamic Study in Cerebral Aneurysms
oaire.awardTitleHemo-Networks - Experimental and computational investigations of the factors influencing blood flow in microvascular networks.
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FEME-MFE%2F099109%2F2008/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FSAU-BEB%2F108728%2F2008/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FSAU-BEB%2F105650%2F2008/PT
oaire.citation.endPage547por
oaire.citation.startPage513por
oaire.citation.titleSingle and two-Phase Flows on Chemical and Biomedical Engineeringpor
oaire.fundingStream5876-PPCDTI
oaire.fundingStream5876-PPCDTI
oaire.fundingStream5876-PPCDTI
person.familyNameLima
person.givenNameRui A.
person.identifier.ciencia-idEE12-C3FB-349D
person.identifier.orcid0000-0003-3428-637X
person.identifier.ridH-5157-2016
person.identifier.scopus-author-id18437397800
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspor
rcaap.typebookPartpor
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