Synthesis of new N-[3-(thieno[3,2-b]pyridine-7-ylthio)phenyl]benzamides as potential inhibitors the tyrosine kinase domain of VEGFR2

Campos, Joana F.; Begouin, Agathe; Peixoto, Daniela; Froufe, Hugo J.C.; Abreu, Rui M.V.; Ferreira, Isabel C.F.R.; Queiroz, Maria João R.P.

http://hdl.handle.net/10198/8688

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Authors

Ferreira, Isabel C.F.R.

Queiroz, Maria João R.P.

Abstract(s)

Angiogenesis, the growth of new vessels from preexisting vasculature, is a critical step in tumor progression [1]. The tyrosine kinase Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) is a crucial mediator in angiogenesis since the VEGF, excreted by the tumor cells, binds to it activating several signaling pathways involved in cell survival and proliferation [2]. Recently thienopyridine derivatives showed to be promising inhibitors of the tyrosine kinase domain of VEGFR2 [3,4]. In this work new N-[3-(thieno[3,2-b]pyridine-7-ylthio)phenyl]benzamides were prepared as potential VEGFR2 inhibitors suggested by rational design, as presented below.

URI

http://hdl.handle.net/10198/8688

Citation

Campos, Joana F.; Begouin, Agathe; Peixoto, Daniela; Froufe, Hugo J.C.; Abeu, Rui M.V.; Ferreira, Isabel C.F.R.; Queiroz, Maria-João R. P. (2013). Synthesis of new N-[3-(thieno[3,2-b]pyridine-7-ylthio)phenyl]benzamides as potential inhibitors the tyrosine kinase domain of VEGFR2. In 1st Symposium on Medicinal Chemistry. Braga