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Synthesis of new N-[3-(thieno[3,2-b]pyridine-7-ylthio)phenyl]benzamides as potential inhibitors the tyrosine kinase domain of VEGFR2

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dc.contributor.authorCampos, Joana F.
dc.contributor.authorBegouin, Agathe
dc.contributor.authorPeixoto, Daniela
dc.contributor.authorFroufe, Hugo J.C.
dc.contributor.authorAbreu, Rui M.V.
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorQueiroz, Maria João R.P.
dc.date.accessioned2013-09-09T14:50:56Z
dc.date.available2013-09-09T14:50:56Z
dc.date.issued2013
dc.description.abstractAngiogenesis, the growth of new vessels from preexisting vasculature, is a critical step in tumor progression [1]. The tyrosine kinase Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) is a crucial mediator in angiogenesis since the VEGF, excreted by the tumor cells, binds to it activating several signaling pathways involved in cell survival and proliferation [2]. Recently thienopyridine derivatives showed to be promising inhibitors of the tyrosine kinase domain of VEGFR2 [3,4]. In this work new N-[3-(thieno[3,2-b]pyridine-7-ylthio)phenyl]benzamides were prepared as potential VEGFR2 inhibitors suggested by rational design, as presented below.por
dc.description.sponsorshipFCT -Portugal for financial support through the NMR Portuguese network (Bruker 400 Avance 111-Univ Minho). FCT and FEDER -COMPETE-QREN-EU for financial support through the research unities PEstC/ QUI/UI686/2011, PEst-OE/AGR/UI0690/2011, the research project PTDC/QUI-QUI/111 060/2009 and the post-Doctoral grant A.B.(SFRH/BPD/36753/2007) also financed by POPH and FSE.por
dc.identifier.citationCampos, Joana F.; Begouin, Agathe; Peixoto, Daniela; Froufe, Hugo J.C.; Abeu, Rui M.V.; Ferreira, Isabel C.F.R.; Queiroz, Maria-João R. P. (2013). Synthesis of new N-[3-(thieno[3,2-b]pyridine-7-ylthio)phenyl]benzamides as potential inhibitors the tyrosine kinase domain of VEGFR2. In 1st Symposium on Medicinal Chemistry. Bragapor
dc.identifier.urihttp://hdl.handle.net/10198/8688
dc.language.isoengpor
dc.peerreviewedyespor
dc.relationPEst-C/QUI/UI686/2011
dc.relationStrategic Project - UI 690 - 2011-2012
dc.titleSynthesis of new N-[3-(thieno[3,2-b]pyridine-7-ylthio)phenyl]benzamides as potential inhibitors the tyrosine kinase domain of VEGFR2por
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleStrategic Project - UI 690 - 2011-2012
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FQUI-QUI%2F111060%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FAGR%2FUI0690%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F36753%2F2007/PT
oaire.citation.conferencePlaceBraga, Portugalpor
oaire.citation.title1st Symposium on Medicinal Chemistry of University of Minhopor
oaire.fundingStream5876-PPCDTI
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamSFRH
person.familyNameAbreu
person.familyNameFerreira
person.givenNameRui M.V.
person.givenNameIsabel C.F.R.
person.identifier144781
person.identifier.ciencia-id0F19-0DE2-12A2
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0002-7745-8015
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id7003290613
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspor
rcaap.typeconferenceObjectpor
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