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Advisor(s)
Abstract(s)
The xurography is a technique that has been used to make molds to produce microchannels. In contrast to soft lithography [1, 2], xurography uses equipments and materials commonly used in the printing industry, such as cutting plotters, vinyl and other materials. The main advantage of this technique is to fabricate microchannels at a reduced cost [3, 4].
The Fahraeus-Lindqvist effect is a well know phenomenon that happens in microcirculation, where red blood cells (RBCs) have tendency to migrate toward the centre of the microtube resulting in a marginal cell-free layer (CFL) at regions adjacent to the wall [5]. Recently several studies showed strong evidence that the formation of the CFL is affected by the geometry of the microchannel [1, 6, 7] and the physiological conditions of the working fluid, such as the hematocrit (Hct) [2, 8].
The main objective of the present work is to fabricate polydimethysiloxane (PDMS) microchannels by using a soft xurography technique in order perform blood flow studies. Additionally, a high-speed video microscopy system is used to measure the CFL thickness in two different geometries, i. e., bifurcations and confluences.
Description
Keywords
Blood flow Xurograpgy Cell free layer Bifurcations
Citation
Pinto, E.; Taboada, B.; Faustino, V.; Cidre, D.; Rodrigues, R.; Miranda, J.; Garcia, V.; Dias, Ricardo; Lima, R. (2013). Blood flow in microchannels manufactured by a low cost technique: xurography. In Eds. Rubio-Hernández F. J. [et al.] Perspectives in Fundamental and Applied Rheology. Gráficas Fernando. p. 285-290. ISBN 978-84-616-5245-7