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Advisor(s)
Abstract(s)
Ganoderma lucidum is one of the most extensively studied mushrooms as a functional food and as a
chemopreventive agent due to its recognized medicinal properties. Some G. lucidum extracts have
shown promising antitumor potential. In this study, the bioactive properties of various extracts of
G. lucidum, from both the fruiting body and the spores, were investigated. The most potent extract
identified was the methanolic fruiting body extract, which inhibited the growth of a gastric cancer cell
line (AGS) by interfering with cellular autophagy and cell cycle.
Description
Keywords
Leukemia cells Colorectal cancer Gene expression Wild mushrooms Apoptosis Proliferation
Pedagogical Context
Citation
Oliveira, Marta; Reis, Filipa S.; Sousa, Diana; Tavares, Catarina; Lima, Raquel T.; Ferreira, Isabel C.F.R.; Santos, Tiago; Vasconcelos, M. Helena (2014). A methanolic extract of Ganoderma lucidum fruiting body inhibits the growth of a gastric cancer cell line and affects cellular autophagy and cell cycle. Food and Function. ISSN 2042-650X. 5:7, p. 1389-1394
Publisher
Royal Society of Chemistry