Repository logo
 
Publication

A methanolic extract of Ganoderma lucidum fruiting body inhibits the growth of a gastric cancer cell line and affects cellular autophagy and cell cycle

2014Journal article Open access
Simple item page
dc.contributor.authorOliveira, Beatriz
dc.contributor.authorReis, Filipa S.
dc.contributor.authorSousa, Diana
dc.contributor.authorTavares, Catarina
dc.contributor.authorLima, Raquel T.
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorSantos, Tiago
dc.contributor.authorVasconcelos, M. Helena
dc.date.accessioned2014-08-14T10:36:28Z
dc.date.available2014-08-14T10:36:28Z
dc.date.issued2014
dc.description.abstractGanoderma lucidum is one of the most extensively studied mushrooms as a functional food and as a chemopreventive agent due to its recognized medicinal properties. Some G. lucidum extracts have shown promising antitumor potential. In this study, the bioactive properties of various extracts of G. lucidum, from both the fruiting body and the spores, were investigated. The most potent extract identified was the methanolic fruiting body extract, which inhibited the growth of a gastric cancer cell line (AGS) by interfering with cellular autophagy and cell cycle.por
dc.description.sponsorshipFundaçao para a Ciencia e a Tecnologia (FCT, Portugal) and COMPETE/QREN/EU for providing financial support to this work (research project PTDC/AGR-ALI/110062/2009), CIMO (strategic project PEst-OE/AGR/UI0690/2011), FCT for the grant of R.T.L. (SFRH/BPD/68787/2010) and QREN for the grants of F.S.R. and D.S. (NORTE-07-0124-FEDER-000023). The authors also thank Dr Gabriela Almeida for technical assistance in the screening assays and Prof. Anabela Martins from the Polytechnic Institute of Bragança for confrmation of the identification of G. lucidum samples. IPATIMUP, Associate Laboratory of the Portuguese Ministry of Science, Technology and Higher Education, is partially supported by FCT.por
dc.identifier.citationOliveira, Marta; Reis, Filipa S.; Sousa, Diana; Tavares, Catarina; Lima, Raquel T.; Ferreira, Isabel C.F.R.; Santos, Tiago; Vasconcelos, M. Helena (2014). A methanolic extract of Ganoderma lucidum fruiting body inhibits the growth of a gastric cancer cell line and affects cellular autophagy and cell cycle. Food and Function. ISSN 2042-650X. 5:7, p. 1389-1394por
dc.identifier.doi10.1039/c4fo00258j
dc.identifier.issn2042-650X
dc.identifier.urihttp://hdl.handle.net/10198/10160
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherRoyal Society of Chemistrypor
dc.relationNORTE-07-0124-FEDER-000023
dc.relationPortuguese Wild Mushrooms: Chemical characterization and functional study of antiproliferative and proapoptotic properties in cancer cell lines
dc.relationStrategic Project - UI 690 - 2011-2012
dc.relationSMALL MOLECULES AS APOPTOSIS INDUCERS IN CANCER CELLS: INVESTIGATION OF THE MECHANISM OF ACTION
dc.subjectLeukemia cellspor
dc.subjectColorectal cancerpor
dc.subjectGene expressionpor
dc.subjectWild mushroomspor
dc.subjectApoptosispor
dc.subjectProliferationpor
dc.titleA methanolic extract of Ganoderma lucidum fruiting body inhibits the growth of a gastric cancer cell line and affects cellular autophagy and cell cyclepor
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitlePortuguese Wild Mushrooms: Chemical characterization and functional study of antiproliferative and proapoptotic properties in cancer cell lines
oaire.awardTitleStrategic Project - UI 690 - 2011-2012
oaire.awardTitleSMALL MOLECULES AS APOPTOSIS INDUCERS IN CANCER CELLS: INVESTIGATION OF THE MECHANISM OF ACTION
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FAGR-ALI%2F110062%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FAGR%2FUI0690%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F68787%2F2010/PT
oaire.citation.endPage1394por
oaire.citation.startPage1389por
oaire.citation.titleFood and Functionpor
oaire.citation.volume5por
oaire.fundingStream5876-PPCDTI
oaire.fundingStream6817 - DCRRNI ID
person.familyNameReis
person.familyNameFerreira
person.givenNameFilipa S.
person.givenNameIsabel C.F.R.
person.identifier144781
person.identifier.ciencia-id391F-AFE1-64C7
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0002-9159-0530
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridI-2093-2013
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id36982144400
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublicationb8d384ae-2134-4735-93a6-0d2febbf9220
relation.isAuthorOfPublicationbd0d1537-2e03-41fb-b27a-140af9c35db8
relation.isAuthorOfPublication.latestForDiscoveryb8d384ae-2134-4735-93a6-0d2febbf9220
relation.isProjectOfPublication59db4b60-8cc2-4f07-a25a-8cfe78f2778f
relation.isProjectOfPublicationc59f09d4-9931-4f2e-babb-ef8bed998be7
relation.isProjectOfPublication506940d4-2643-4c8a-a077-9a30b043163a
relation.isProjectOfPublication.latestForDiscovery59db4b60-8cc2-4f07-a25a-8cfe78f2778f

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Artigo 216.pdf
Size:
315.59 KB
Format:
Adobe Portable Document Format
Description:
Documento publicado
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.75 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

CIMO - Artigos em Revistas Indexados à WoS/Scopus