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Associations Between Pain Intensity and Inflammatory Profile in Women with Android and Gynoid Obesity Diagnosed with Chronic Pain: An Observational Study

2025Journal article Open access
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datacite.subject.fosCiências Médicas::Ciências da Saúde
datacite.subject.fosCiências Sociais::Outras Ciências Sociais
datacite.subject.sdg04:Educação de Qualidade
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorCota, Cecília Cristina
dc.contributor.authorMiranda-Castro, Stefani
dc.contributor.authorSouza-Gomes, Antônio Felipe
dc.contributor.authorLeite, Luciano Bernardes
dc.contributor.authorForte, Pedro
dc.contributor.authorMonteiro, António M.
dc.contributor.authorPereira, William Valadares Campos
dc.contributor.authorMoura, Samara Silva
dc.contributor.authorNunes-Silva, Albená
dc.date.accessioned2025-11-06T12:18:49Z
dc.date.available2025-11-06T12:18:49Z
dc.date.issued2025
dc.description.abstractThere are different types of obesity, and the metabolic conditions associated with these phenotypes are also heterogeneous. Overweight and obesity are not only associated with pain but are also identified as risk factors for the development of pain. Objective: This study aimed to compare the levels of inflammatory biomarkers, counting of immune cells, and chronic pain between android and gynoid female patients with obesity. Method: Thirty (n = 30) women took part in this study (18 androids, age: 50.61 +/- 9.41 and 12 gynoids, age: 50.67 +/- 9.45). The participants underwent anamnesis, Visual Numeric Scale (VNS), dual-energy X-ray absorptiometry, and blood sampling for the analysis of leukocytes, C-reactive protein (CRP), and interleukin (IL)-6. Results: The number of total leukocytes in the blood was not different when comparing the android group (6045 mu L) with the gynoid group (5230 mu L). No differences were observed for neutrophils (3440 mu L in android and 3017 mu L in gynoid), lymphocytes (2208 mu L in android and 2115 mu L in gynoid), for monocytes (429.7 mu L in android and 392.8 mu L in gynoid), and basophils (17.27 mu L in android and 15.41 mu L in gynoid). However, there was a significant difference between the number of eosinophils when comparing the android group (137.6 mu L) with the gynoid group (204.9 mu L), p = 0.04. Although both groups presented CRP values above 0.3 mg/dL-indicative of low-grade inflammation-no statistically significant difference was observed. Similarly, no difference was found in pain intensity between groups, as measured by the Visual Numeric Scale (VNS). Conclusions: Although most inflammatory and pain markers did not differ between groups, the higher eosinophil count in the gynoid phenotype suggests immunological distinctions between obesity types. These findings underline the importance of considering body fat distribution in clinical assessments of inflammation and chronic pain in women with obesity.eng
dc.description.sponsorshipWe would like to thank the Prefeitura de Mariana/MG for their support. L.B.L. also acknowledges the Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG) for the scholarship.
dc.identifier.citationCota, Cecília Cristina, Stefani Miranda-Castro, Antônio Felipe Souza-Gomes, Luciano Bernardes Leite, Pedro Forte, António M. Monteiro, William Valadares Campos Pereira, Samara Silva de Moura, and Albená Nunes-Silva (2025) Associations Between Pain Intensity and Inflammatory Profile in Women with Android and Gynoid Obesity Diagnosed with Chronic Pain: An Observational Study. Journal of Clinical Medicine. ISSN 2077-0383. 14:12, p. 1-13
dc.identifier.doi10.3390/jcm14124170
dc.identifier.issn2077-0383
dc.identifier.urihttp://hdl.handle.net/10198/34979
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relation.ispartofJournal of Clinical Medicine
dc.rights.urihttp://creativecommons.org/licenses/by-nd/4.0/
dc.subjectAndroid
dc.subjectChronic pain
dc.subjectC-reactive protein
dc.subjectGynoid
dc.subjectInflammation
dc.subjectInterleukin-6
dc.titleAssociations Between Pain Intensity and Inflammatory Profile in Women with Android and Gynoid Obesity Diagnosed with Chronic Pain: An Observational Studyeng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage13
oaire.citation.issue12
oaire.citation.startPage1
oaire.citation.titleJournal of Clinical Medicine
oaire.citation.volume14
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameForte
person.familyNameMonteiro
person.givenNamePedro
person.givenNameAntónio M.
person.identifier.ciencia-id351B-B16B-79C7
person.identifier.ciencia-idC41C-6CCD-A1F0
person.identifier.orcid0000-0003-0184-6780
person.identifier.orcid0000-0003-4467-1722
relation.isAuthorOfPublication3ecc6d1b-07a4-40d7-81f4-df6fd7b3d5b0
relation.isAuthorOfPublication5b5d8601-e683-42d5-a1b5-c8e29a4e0a41
relation.isAuthorOfPublication.latestForDiscovery5b5d8601-e683-42d5-a1b5-c8e29a4e0a41

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