Associations Between Pain Intensity and Inflammatory Profile in Women with Android and Gynoid Obesity Diagnosed with Chronic Pain: An Observational Study

There are different types of obesity, and the metabolic conditions associated with these phenotypes are also heterogeneous. Overweight and obesity are not only associated with pain but are also identified as risk factors for the development of pain. Objective: This study aimed to compare the levels of inflammatory biomarkers, counting of immune cells, and chronic pain between android and gynoid female patients with obesity. Method: Thirty (n = 30) women took part in this study (18 androids, age: 50.61 +/- 9.41 and 12 gynoids, age: 50.67 +/- 9.45). The participants underwent anamnesis, Visual Numeric Scale (VNS), dual-energy X-ray absorptiometry, and blood sampling for the analysis of leukocytes, C-reactive protein (CRP), and interleukin (IL)-6. Results: The number of total leukocytes in the blood was not different when comparing the android group (6045 mu L) with the gynoid group (5230 mu L). No differences were observed for neutrophils (3440 mu L in android and 3017 mu L in gynoid), lymphocytes (2208 mu L in android and 2115 mu L in gynoid), for monocytes (429.7 mu L in android and 392.8 mu L in gynoid), and basophils (17.27 mu L in android and 15.41 mu L in gynoid). However, there was a significant difference between the number of eosinophils when comparing the android group (137.6 mu L) with the gynoid group (204.9 mu L), p = 0.04. Although both groups presented CRP values above 0.3 mg/dL-indicative of low-grade inflammation-no statistically significant difference was observed. Similarly, no difference was found in pain intensity between groups, as measured by the Visual Numeric Scale (VNS). Conclusions: Although most inflammatory and pain markers did not differ between groups, the higher eosinophil count in the gynoid phenotype suggests immunological distinctions between obesity types. These findings underline the importance of considering body fat distribution in clinical assessments of inflammation and chronic pain in women with obesity.

Keywords

Android Chronic pain C-reactive protein Gynoid Inflammation Interleukin-6

URI

http://hdl.handle.net/10198/34979

Citation

Cota, Cecília Cristina, Stefani Miranda-Castro, Antônio Felipe Souza-Gomes, Luciano Bernardes Leite, Pedro Forte, António M. Monteiro, William Valadares Campos Pereira, Samara Silva de Moura, and Albená Nunes-Silva (2025) Associations Between Pain Intensity and Inflammatory Profile in Women with Android and Gynoid Obesity Diagnosed with Chronic Pain: An Observational Study. Journal of Clinical Medicine. ISSN 2077-0383. 14:12, p. 1-13