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Development of statin-like and ergosterol enriched extracts from mushrooms bioresidues

2022Conference object Open access
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dc.contributor.authorUeda, Jonata Massao
dc.contributor.authorBenhassen, Yosra
dc.contributor.authorCarocho, Márcio
dc.contributor.authorBarros, Lillian
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorHeleno, Sandrina A.
dc.date.accessioned2023-03-15T16:04:32Z
dc.date.available2023-03-15T16:04:32Z
dc.date.issued2022
dc.description.abstractAlthough cholesterol is essential for the functioning of the human body, its excess is responsible for causing atherosclerosis, along with several other diseases that affect the bones, liver, hormones, and immune system1. As a natural solution, mushrooms are being studied for their ability to reduce cholesterol due to their richness in molecules capable of reducing both cholesterol absorption and synthesis2,3. Therefore, the present work investigated two mushrooms species (Agaricus bisporus L. and Pleurotus ostreatus L.), aiming at extracting the highest contents of statins and ergosterol. Ultrasound assisted extraction (UAE) optimization was performed followed by quantification of ergosterol and statins of the extracts by HPLC-UV4,5, as well as the effect of the temperature on both extractions (with and without iced bath), since statins are described as sensitive to high temperatures. For A. bisporus, there was no significant differences in the concentration of ergosterol and pravastatin when applying ice bath during the UAE. For P. ostreatus, the ice bath resulted in a 6% decrease in the ergosterol concentration and a 35% increase in pravastatin content, suggesting that the best extraction method to obtain an extract rich in hypocholesterolemic compounds is a cold extraction. For optimization, the P. ostreatus extract revealed the highest amount of pravastatin and ergosterol (63.85 and 23.95 mg/g of extract, respectively), in which the best extraction conditions were 400 W of ultrasonic power, 4 minutes and 44 seconds of extraction time, and 15.2 g/L of solid:liquid ratio, using methanol as solvent, besides using an ultrasound extraction with ice bath.pt_PT
dc.description.sponsorshipThe authors are grateful to the Foundation for Science and Technology (FCT, Portugal) for financial support through national funds FCT/MCTES to the CIMO (UIDB/00690/2020 and UIDP/00690/2020) and SusTEC (LA/P/0007/2021). S. Heleno and M. Carocho thank FCT for their individual employment program–contract (CEECIND/00831/2018, CEECIND/03040/2017), RC Calhelha and L. Barros also thank to the national funding by FCT through the institutional scientific employment program–contract for her contract.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationUeda, Jonata Massao; Benhassen, Yosra; Carocho, Márcio; Barros, Lillian; Calhelha, Ricardo C.; Heleno, Sandrina A. (2022). Development of statin-like and ergosterol enriched extracts from mushrooms bioresidues. In Livro de Resumos do 12º Encontro Nacional de Cromatografia & XIV WARPA. Aveiropt_PT
dc.identifier.isbn978-989-8124-37-1
dc.identifier.urihttp://hdl.handle.net/10198/27752
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSociedade Portuguesa de Químicapt_PT
dc.relationLA/P/0007/2021pt_PT
dc.relationMountain Research Center
dc.relationMountain Research Center
dc.relationNot Available
dc.relationNot Available
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectErgosterolpt_PT
dc.subjectMushroompt_PT
dc.subjectResearch Subject Categories::TECHNOLOGY::Chemical engineering::Food technologypt_PT
dc.titleDevelopment of statin-like and ergosterol enriched extracts from mushrooms bioresiduespt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleMountain Research Center
oaire.awardTitleMountain Research Center
oaire.awardTitleNot Available
oaire.awardTitleNot Available
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND 2018/CEECIND%2F00831%2F2018%2FCP1578%2FCT0001/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND 2017/CEECIND%2F03040%2F2017%2FCP1403%2FCT0001/PT
oaire.citation.conferencePlaceAveiropt_PT
oaire.citation.endPage79pt_PT
oaire.citation.startPage79pt_PT
oaire.citation.titleLivro de Resumos do 12º Encontro Nacional de Cromatografia & XIV WARPApt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamCEEC IND 2018
oaire.fundingStreamCEEC IND 2017
person.familyNameUeda
person.familyNameCarocho
person.familyNameBarros
person.familyNameCalhelha
person.familyNameHeleno
person.givenNameJonata Massao
person.givenNameMárcio
person.givenNameLillian
person.givenNameRicardo C.
person.givenNameSandrina A.
person.identifierawbWiiMAAAAJ&hl
person.identifier469085
person.identifier.ciencia-id4417-F90B-68A3
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person.identifier.ciencia-idF313-E3CE-554E
person.identifier.ciencia-id8B18-3095-6FC9
person.identifier.orcid0000-0002-1452-3764
person.identifier.orcid0000-0002-8978-4547
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0001-7224-1098
person.identifier.ridJ-3600-2013
person.identifier.ridJ-2172-2014
person.identifier.ridL-5951-2014
person.identifier.scopus-author-id57222522617
person.identifier.scopus-author-id52463229800
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id30067731800
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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