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In vitro blood flow behaviour in microchannels with simple and complex geometries

2012Book part Open access
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dc.contributor.authorGarcia, Valdemar
dc.contributor.authorDias, Ricardo P.
dc.contributor.authorLima, Rui A.
dc.date.accessioned2012-04-10T11:34:19Z
dc.date.available2012-04-10T11:34:19Z
dc.date.issued2012
dc.description.abstractOver the years, various experimental methods have been applied in an effort to understand the blood flow behaviour in microcirculation. The development of optical experimental techniques has contributed to obtain possible explanations on the way the blood flows through microvessels. In recent years, due to advances in computers, optics, and digital image processing techniques, it has become possible to combine a conventional particle image velocimetry (PIV) system with an inverted microscope and consequently improve both spatial and temporal resolution. The present review outlines our most relevant studies on the flow properties of blood at a microscale level by using current micro-PIV and confocal micro-PIV techniques. In this chapter, our recent studies about in vitro blood flow behaviour in microchannels both in straight and with complex geometries are presented. In straight microchannels we present some phenomena such as Fahraeus effect and Fahraeus-Lindqvist effect, the flow of particles and red blood cells (RBCs) in diluted suspensions, the flow of RBCs in concentrated suspensions, the cell-free layer and sedimentations effects. The most recent studies in blood flow through complex geometries such as bifurcations, confluences and stenosis are also reviewed. By using a chromatographic method, the flow of RBC s through a network of microcapillaries is presented.por
dc.description.sponsorshipThe authors acknowledge the financial support provided by: PTDC/SAUBEB/108728/2008, PTDC/SAU-BEB/105650/2008 and PTDC/EME-MFE/099109/2008 from the FCT (Science and Technology Foundation) and COMPETE, Portugal.por
dc.identifier.citationGarcia, Valdemar; Dias, Ricardo ; Lima, R. (2012). In vitro blood flow behaviour in microchannels with simple and complex geometries. In Applied Biological Engineering - Principles and Practice. InTech. p. 393-416. ISBN 978-953-51-0412-4. p. 393-416.por
dc.identifier.isbn978-953-51-0412-4
dc.identifier.urihttp://hdl.handle.net/10198/6765
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherInTechpor
dc.relationHemo-Networks - Experimental and computational investigations of the factors influencing blood flow in microvascular networks.
dc.relationANEURYSM - Hemodynamic Study in Cerebral Aneurysms
dc.relation.publisherversionhttp://www.intechopen.com/articles/show/title/in-vitro-blood-flow-behaviour-in-microchannels-with-simple-and-complex-geometriespor
dc.subjectBlood flowpor
dc.subjectMicrochannelspor
dc.subjectConfocal micro-PIV/PTVpor
dc.subjectMicrocirculationpor
dc.subjectRed blood cellspor
dc.subjectRed blood cellspor
dc.titleIn vitro blood flow behaviour in microchannels with simple and complex geometriespor
dc.typebook part
dspace.entity.typePublication
oaire.awardTitleHemo-Networks - Experimental and computational investigations of the factors influencing blood flow in microvascular networks.
oaire.awardTitleANEURYSM - Hemodynamic Study in Cerebral Aneurysms
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FSAU-BEB%2F108728%2F2008/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FEME-MFE%2F099109%2F2008/PT
oaire.citation.endPage416por
oaire.citation.startPage393por
oaire.citation.titleApplied Biological Engineering - Principles and Practicepor
oaire.fundingStream5876-PPCDTI
oaire.fundingStream5876-PPCDTI
person.familyNameGarcia
person.familyNameDias
person.familyNameLima
person.givenNameValdemar
person.givenNameRicardo
person.givenNameRui A.
person.identifier.ciencia-idEE12-C3FB-349D
person.identifier.orcid0000-0002-3941-2438
person.identifier.orcid0000-0003-1503-998X
person.identifier.orcid0000-0003-3428-637X
person.identifier.ridH-5157-2016
person.identifier.scopus-author-id7102885151
person.identifier.scopus-author-id18437397800
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspor
rcaap.typebookPartpor
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