Advisor(s)
Abstract(s)
Centaurea raphanina subsp. mixta (DC.) Runemark is a wild edible species endemic to Greece.
This study evaluated the chemical composition and bioactive properties of wild and cultivated
C. raphanina subsp. mixta plants. Wild plants had higher nutritional value than cultivated ones,
whereas cultivated plants contained more tocopherols. Glucose and sucrose were higher in cultivated
plants and trehalose in wild ones. Oxalic and total organic acids were detected in higher amounts in
cultivated samples. The main fatty acids were -linolenic, linoleic and palmitic acid, while wild plants
were richer in polyunsaturated fatty acids. Two pinocembrin derivatives were the main phenolic
compounds being detected in higher amounts in wild plants. Regarding the antioxidant activity, wild
and cultivated plants were more e ective in the oxidative haemolysis (OxHLIA) and thiobarbituric
acid reactive substances (TBARS) assays, respectively. Moreover, both extracts showed moderate
cytotoxicity in non-tumor cell lines (PLP2), while cultivated plants were more e ective against cervical
carcinoma (HeLa), breast carcinoma (MCF-7) and non-small lung cancer (NCI-H460) cell lines. Finally,
wild plants showed higher antimicrobial activity than cultivated plants against specific pathogens.
In conclusion, the cultivation of C. raphanina subsp. mixta showed promising results in terms of
tocopherols content and antiproliferative e ects, however further research is needed to decrease
oxalic acid content.
Description
Keywords
Antimicrobial activities Antioxidant activity Cytotoxic effects Organic acids Phenolic compounds
Pedagogical Context
Citation
Petropoulos, Spyridon A.; Fernandes, Ângela; Dias, Maria Ines; Pereira, Carla; Calhelha, Ricardo; Di Gioia, Francesco; Tzortzakis, Nikolaos; Ivanov, Marija; Sokovic, Marina; Barros, Lillian; Ferreira, Isabel C.F.R. (2020). Wild and cultivated centaurea raphanina subsp. Mixta: A valuable source of bioactive compounds. Antioxidants. ISSN 2076-3921. 9:4, p. 1-23