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Wild and cultivated centaurea raphanina subsp. Mixta: A valuable source of bioactive compounds

2020Journal article Open access
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dc.contributor.authorPetropoulos, Spyridon Α.
dc.contributor.authorFernandes, Ângela
dc.contributor.authorDias, Maria Inês
dc.contributor.authorPereira, Carla
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorDi Gioia, Francesco
dc.contributor.authorTzortzakis, Nikolaos
dc.contributor.authorIvanov, Marija
dc.contributor.authorSoković, Marina
dc.contributor.authorBarros, Lillian
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2018-02-19T10:00:00Z
dc.date.accessioned2020-06-22T10:18:20Z
dc.date.available2018-01-19T10:00:00Z
dc.date.available2020-06-22T10:18:20Z
dc.date.issued2020
dc.description.abstractCentaurea raphanina subsp. mixta (DC.) Runemark is a wild edible species endemic to Greece. This study evaluated the chemical composition and bioactive properties of wild and cultivated C. raphanina subsp. mixta plants. Wild plants had higher nutritional value than cultivated ones, whereas cultivated plants contained more tocopherols. Glucose and sucrose were higher in cultivated plants and trehalose in wild ones. Oxalic and total organic acids were detected in higher amounts in cultivated samples. The main fatty acids were -linolenic, linoleic and palmitic acid, while wild plants were richer in polyunsaturated fatty acids. Two pinocembrin derivatives were the main phenolic compounds being detected in higher amounts in wild plants. Regarding the antioxidant activity, wild and cultivated plants were more e ective in the oxidative haemolysis (OxHLIA) and thiobarbituric acid reactive substances (TBARS) assays, respectively. Moreover, both extracts showed moderate cytotoxicity in non-tumor cell lines (PLP2), while cultivated plants were more e ective against cervical carcinoma (HeLa), breast carcinoma (MCF-7) and non-small lung cancer (NCI-H460) cell lines. Finally, wild plants showed higher antimicrobial activity than cultivated plants against specific pathogens. In conclusion, the cultivation of C. raphanina subsp. mixta showed promising results in terms of tocopherols content and antiproliferative e ects, however further research is needed to decrease oxalic acid content.
dc.description.sponsorshipF.D.G. contribution was supported by the USDA National Institute of Food and Agriculture and Hatch Appropriations under Project #PEN04723 and Accession #1020664. The authors are grateful to the Foundation for Science and Technology (FCT, Portugal) for financial support through national funds FCT/MCTES to CIMO (UIDB/00690/2020). L. Barros, A. Fernandes, M.I. Dias and R. Calhelha also thank the national funding by FCT–Foundation for Science and Technology, P.I., through the institutional scientific employment program-contract for their contracts. C. Pereira contract though the celebration of program-contract foreseen in No. 4, 5 and 6 of article 23º of Decree-Law No. 57/2016, of 29th August, amended by Law No. 57/2017, of 19th July. The authors are grateful to FEDER-Interreg España-Portugal programme for financial support through the project 0377_Iberphenol_6_E; and to Ministry of Education, Science and Technological Development of Republic of Serbia (451-03-68/2020-14/200007).
dc.description.versioninfo:eu-repo/semantics/publishedVersionen_EN
dc.identifier.citationPetropoulos, Spyridon A.; Fernandes, Ângela; Dias, Maria Ines; Pereira, Carla; Calhelha, Ricardo; Di Gioia, Francesco; Tzortzakis, Nikolaos; Ivanov, Marija; Sokovic, Marina; Barros, Lillian; Ferreira, Isabel C.F.R. (2020). Wild and cultivated centaurea raphanina subsp. Mixta: A valuable source of bioactive compounds. Antioxidants. ISSN 2076-3921. 9:4, p. 1-23en_EN
dc.identifier.doi10.3390/antiox9040314en_EN
dc.identifier.urihttp://hdl.handle.net/10198/19607
dc.language.isoeng
dc.peerreviewedyesen_EN
dc.relation04723
dc.subjectAntimicrobial activitiesen_EN
dc.subjectAntioxidant activityen_EN
dc.subjectCytotoxic effectsen_EN
dc.subjectOrganic acidsen_EN
dc.subjectPhenolic compoundsen_EN
dc.titleWild and cultivated centaurea raphanina subsp. Mixta: A valuable source of bioactive compoundsen_EN
dc.typejournal article
dspace.entity.typePublication
person.familyNameFernandes
person.familyNameDias
person.familyNamePereira
person.familyNameCalhelha
person.familyNameBarros
person.familyNameFerreira
person.givenNameÂngela
person.givenNameMaria Inês
person.givenNameCarla
person.givenNameRicardo C.
person.givenNameLillian
person.givenNameIsabel C.F.R.
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rcaap.rightsopenAccessen_EN
rcaap.typearticleen_EN
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