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Gut Microbiota as an Endocrine Organ: Unveiling Its Role in Human Physiology and Health

2024Journal article Open access
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dc.contributor.authorPires, Lara
dc.contributor.authorGonzalez-Paramás, Ana Maria
dc.contributor.authorHeleno, Sandrina A.
dc.contributor.authorCalhelha, Ricardo C.
dc.date.accessioned2024-09-30T09:03:20Z
dc.date.available2024-09-30T09:03:20Z
dc.date.issued2024
dc.description.abstractThe gut microbiota, recognised for its vital functions in host health, operates as an endocrine organ, exerting systemic effects beyond the gastrointestinal tract. This “virtual organ” produces hormones that influence distal organs, including the brain. With its diverse microbial composition, the gut microbiota surpasses the biochemical complexity of traditional endocrine organs, generating neurotransmitters like GABA, dopamine, and serotonin. Despite challenges in culturing gut bacteria, advances in research methodologies have elucidated their role in behaviour, metabolism, appetite, and insulin resistance. As microbial endocrinology continues to evolve, further exploration of the intricate connections between hormones and the microbiome are anticipated, highlighting hormones’ pivotal role in the dynamic host–microbiota relationship.pt_PT
dc.description.sponsorshipThe authors are grateful to the Foundation for Science and Technology (FCT, Portugal) for financial support through national funds FCT/MCTES (PIDDAC) to CIMO, UIDB/00690/2020 (https://doi.org/10.54499/UIDB/00690/2020) and UIDP/00690/2020 (https://doi.org/10.54499/UIDP/00690/2020) and SusTEC, LA/P/0007/2020 (https://doi.org/10.54499/LA/P/0007/2020), and through the institutional scientific employment program-contract with Sandrina A. Heleno and through the Mush4Chol project (https://doi.org/10.54499/2022.08844.PTDC).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPires, Lara; Gonzalez-Paramás, Ana Maria; Heleno, Sandrina A.; Calhelha, Ricardo C. (2024). Gut Microbiota as an Endocrine Organ: Unveiling Its Role in Human Physiology and Health. Applied Sciences. ISSN 2076-3417. 14:20, p. 1-30pt_PT
dc.identifier.doi10.3390/app14209383pt_PT
dc.identifier.issn2076-3417
dc.identifier.urihttp://hdl.handle.net/10198/30294
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationMountain Research Center
dc.relationMountain Research Center
dc.relationAssociate Laboratory for Sustainability and Tecnology in Mountain Regions
dc.relationDevelopment of an efficient hypocholesterolemic formulation from mushroom bioresidues through a sustainable integrated strategy.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectGut microbiotapt_PT
dc.subjectEndocrine organpt_PT
dc.subjectVirtual organpt_PT
dc.subjectNeurotransmitters
dc.subjectMicrobial endocrinology
dc.subjectIntricate connections
dc.titleGut Microbiota as an Endocrine Organ: Unveiling Its Role in Human Physiology and Health
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMountain Research Center
oaire.awardTitleMountain Research Center
oaire.awardTitleAssociate Laboratory for Sustainability and Tecnology in Mountain Regions
oaire.awardTitleDevelopment of an efficient hypocholesterolemic formulation from mushroom bioresidues through a sustainable integrated strategy.
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0007%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Concurso de Projetos de I&D em Todos os Domínios Científicos - 2022/2022.08844.PTDC/PT
oaire.citation.endPage30
oaire.citation.issue20
oaire.citation.startPage1
oaire.citation.volume14pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamConcurso de Projetos de I&D em Todos os Domínios Científicos - 2022
person.familyNameHeleno
person.familyNameCalhelha
person.givenNameSandrina A.
person.givenNameRicardo C.
person.identifier.ciencia-id8B18-3095-6FC9
person.identifier.ciencia-idF313-E3CE-554E
person.identifier.orcid0000-0001-7224-1098
person.identifier.orcid0000-0002-6801-4578
person.identifier.ridL-5951-2014
person.identifier.ridJ-2172-2014
person.identifier.scopus-author-id30067731800
person.identifier.scopus-author-id6507978333
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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